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Gene Page - CG Number : CG10002
Gene Summary - CG10002:

CG10002: The gene fork head is referred to in FlyBase by the symbol Dmel\fkh (CG10002, FBgn0000659). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: negative regulation of programmed cell death; Malpighian tubule morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; salivary gland development; ecdysone-mediated induction of salivary gland cell autophagic cell death; DNA endoreduplication; negative regulation of multicellular organism growth; salivary gland morphogenesis; negative regulation of cell growth. 31 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system; multicellular structure; organ system subdivision; non-connected developing system; extended germ band embryo; late extended germ band embryo; imaginal precursor; portion of tissue; adult segment; embryonic/larval hemocoel; larval head segment; embryonic stomatogastric nervous system; embryonic hindgut; ectoderm derivative; cephalopharyngeal skeleton; embryonic foregut; endoderm derivative. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Fork-head N-terminal; Forkhead box protein, C-terminal; Transcription factor, fork head; Transcription factor, fork head, conserved site; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.

Gene summary for CG10002 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10002:CG10002 is not perturbed in primary screen.
CG10002 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) NuCirc-(fld) NuFluct+(fld) NuSize+(fld) Okt+(fld) Rto1+ SP_Fint4+
CG10002 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10002.
Cell Count:
CG_NumberCategoryR1R2R3
CG10002Primary screen520938408
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10002:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181197-0.187527755-0.2438327160.1746176991.1849145450.713174273-0.0952227870.743286278-0.4923641630.6858889891.1433552781.783316888-0.3263018330.9231772530.8913335090.9089057231.0037005991.9369606551.2220273991.9012258070.9481357531.980766423-0.459320001-0.277678222
1821194.5577965290.255656578-0.2099989571.1574457860.5188108631.9103427711.2001981261.391230382.5050613121.359189917-0.6549656950.6902392271.2267505620.351269712-0.3752125120.3016705814.1420350283.7896076011.9306597362.126454380.7728012230.5082268520.960758571
183269-0.222526789-0.647113388-0.616981423-0.1004326440.3133759840.065347002-0.0971560020.0221459250.4388659750.2390352860.6853499190.1297095640.208602557-0.109474521-0.460067243-0.3288510790.3566402590.6432470040.796805760.5354766621.5801640330.203322636-0.768323138
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10002Slide17C0.9320.8350.7881.325
CG10002Slide17O0.0381.1671.1981.150
CG10002Slide17P0.7400.7050.7501.316
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10002 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
anti-apoptosisGO:0006916inferred from mutant phenotype
salivary gland morphogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with MGD:Foxa2; MGI:MGI:1347476
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with MGD:Foxa2; MGI:MGI:1347476
sequence-specific DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10002 in FlyBase
FLIGHTClick here to see CG10002 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10002 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10002
Entrez GeneEntrez Gene page for CG10002
UniprotUniprot page for CG10002

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)