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Gene Page - CG Number : CG10023
Gene Summary - CG10023:

CG10023: The gene Focal adhesion kinase is referred to in FlyBase by the symbol Dmel\Fak (CG10023, FBgn0020440). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; regulation of cell shape. 18 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval optic stalk; bouton; synapse; subretinal glial cell. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Band 4.1 domain; FERM central domain; FERM domain; Focal adhesion kinase, targeting (FAT) domain; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages.

Gene summary for CG10023 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10023:CG10023 is not perturbed in primary screen.
CG10023 is perturbed in following parameters in classification assay (fluid): LP_Fint1+ NuCirc-(fld) Rto1+ SP_Fint1+
CG10023 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10023.
Cell Count:
CG_NumberCategoryR1R2R3
CG10023Primary screen342880525
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10023:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181206-0.728800042-0.3942428810.282684586-0.745029543-0.110324265-0.708189156-0.882070571-1.205231351-0.493457736-0.0089056750.615125514-0.3182957060.4688179470.33532069-0.7854818390.5642641810.5578937530.299041840.355900843-0.2978317321.2196326671.0751592862.200596735
1821101.4300369090.9896829181.8724834962.2679085360.13532722-0.7642510490.829892599-0.760963501-0.02928693-0.041123923-0.4278770380.2477329510.111892129-0.9169708660.8107586620.2375916090.60297434-0.1105223260.7765205310.1466535241.691149140.065213580.069843938
1832600.790749101-0.163766985-0.380050858-0.6497723520.6991133880.6500553020.7149636290.712103460.317801588-2.009141335-1.076323114-0.8462379790.8114950051.5692492830.4052303710.744134603-0.070453556-1.421451734-2.3511408960.371728221-0.139551218-0.360279513-0.493554297
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10023Slide17C0.6511.2561.0720.881
CG10023Slide17O0.4391.0300.9510.909
CG10023Slide17P0.3091.6331.4180.883
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10023 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
integrin-mediated signaling pathwayGO:0007229inferred from sequence or structural similarity
cytoskeletal anchoring at plasma membrane
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
focal adhesionGO:0005925inferred from sequence or structural similarity
cytoskeleton
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein tyrosine kinase activityGO:0004713inferred from sequence or structural similarity
protein tyrosine kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10023 in FlyBase
FLIGHTClick here to see CG10023 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10023 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10023
Entrez GeneEntrez Gene page for CG10023
UniprotUniprot page for CG10023

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)