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Gene Page - CG Number : CG1004
Gene Summary - CG1004:

CG1004: The gene rhomboid is referred to in FlyBase by the symbol Dmel\rho (CG1004, FBgn0004635). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: serine-type endopeptidase activity. There is experimental evidence for 18 unique biological process terms, many of which group under: biological regulation; post-embryonic organ morphogenesis; cell fate commitment; appendage development; cellular process; system development; learning or memory; instar larval or pupal morphogenesis; system process; response to organic substance; cellular component organization or biogenesis; genital disc development; associative learning; stem cell differentiation; oenocyte development; digestive tract development. 75 alleles are reported. The phenotypes of these alleles are annotated with 163 unique terms, many of which group under: organ system; hypodermal muscle of larval abdomen; organ system subdivision; larval abdominal segment; adult segment; embryonic/larval neuron; thoracic segment; hypodermal muscle of larval abdominal 2; external compound sense organ; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase S54, rhomboid; Peptidase S54, rhomboid domain; Peptidase S54, rhomboid, metazoan. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages.

Gene summary for CG1004 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1004:CG1004 is perturbed in following parameters in primary screen: NuSize
CG1004 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1004.
Cell Count:
CG_NumberCategoryR1R2R3
CG1004Primary screen455682319
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1004:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG1004 is not tested in classification assay
Integrated Annotations for CG1004 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
imaginal disc-derived wing vein specificationGO:0007474traceable author statement
peripheral nervous system development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity
Golgi apparatus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
serine-type endopeptidase activityGO:0004252inferred from mutant phenotype inferred from genetic interaction with spi inferred from direct assay inferred from sequence model
Other annotations
DatabaseLink
FlyBaseClick here to see CG1004 in FlyBase
FLIGHTClick here to see CG1004 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1004 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1004
Entrez GeneEntrez Gene page for CG1004
UniprotUniprot page for CG1004

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)