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Gene Page - CG Number : CG10043
Gene Summary - CG10043:

CG10043: The gene rho-type guanine exchange factor is referred to in FlyBase by the symbol Dmel\rtGEF (CG10043, FBgn0015803). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process: regulation of synapse organization. 14 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; NMJ bouton; postsynaptic membrane; synaptic vesicle. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Dbl homology (DH) domain; Pleckstrin homology domain; Pleckstrin homology-like domain; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during late pupal stages.

Gene summary for CG10043 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10043:CG10043 is not perturbed in primary screen.
CG10043 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10043.
Cell Count:
CG_NumberCategoryR1R2R3
CG10043Primary screen318828493
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10043:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1812170.2230899460.548402722-0.4595420020.082082667-0.118120632-0.012278257-0.417289367-0.0593219580.7441313746.0282431023.488947847-0.2890274262.353509251.5450491984.6769940010.2022442056.114322984.841812199.2453194291.1987846472.8347158075.0034290381.091232951
182692.7479995030.958940795-0.5116387252.4850669210.369393960.757538740.8264269110.883606771.7608121641.9323691050.2999890851.4919519170.5163016440.247098470.4985111890.5790180771.6347774042.7912817571.7267210121.1962477853.3915465511.137197926-0.480902327
1832190.857713516-0.5688278610.164295540.0900523890.0186319860.0984138310.0283744030.0838769470.2105990510.8409889750.4966292030.378371340.4239638621.058857998-0.659148777-0.1347369830.779078623-0.0718960791.3219617380.2527493362.330821972-0.571257122-0.50628352
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10043 is not tested in classification assay
Integrated Annotations for CG10043 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of synapse organizationGO:0050807inferred from mutant phenotype
regulation of Rho protein signal transduction
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
intracellularGO:0005622inferred from electronic annotation with InterPro:IPR000219
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
guanyl-nucleotide exchange factor activityGO:0005085inferred from sequence or structural similarity
Rho guanyl-nucleotide exchange factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10043 in FlyBase
FLIGHTClick here to see CG10043 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10043 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10043
Entrez GeneEntrez Gene page for CG10043
UniprotUniprot page for CG10043

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)