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Gene Page - CG Number : CG10060
Gene Summary - CG10060:

CG10060: The gene G protein αi subunit 65A is referred to in FlyBase by the symbol Dmel\G-iα65A (CG10060, FBgn0001104). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; DNA binding. There is experimental evidence that it is involved in the biological process: asymmetric protein localization involved in cell fate determination; asymmetric neuroblast division; establishment of spindle orientation; establishment of glial blood-brain barrier; cortical actin cytoskeleton organization; septate junction assembly; regulation of protein localization; asymmetric cell division; ventral cord development. 33 alleles are reported. The phenotypes of these alleles are annotated with: RP2 neuron; neuroblast; embryonic neuroblast; chaeta; medial triple row; RP2sib neuron; EL neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: G protein alpha subunit, helical insertion; G-protein alpha subunit, group I; Guanine nucleotide binding protein (G-protein), alpha subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10060 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10060:CG10060 is not perturbed in primary screen.
CG10060 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10060.
Cell Count:
CG_NumberCategoryR1R2R3
CG10060Primary screen522829422
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10060:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181226-0.093228301-0.216683503-0.276164482-0.3220556930.991481261.0781653330.6588840790.9752567891.3525171840.371439330.1805957661.2256014180.6586323480.272099903-0.0689345760.2430017860.3443380570.4381255160.7390728451.2065982580.334246056-0.175252742-0.155263686
182903.046793161.4384961660.1585288271.9623460540.2334031820.735422091.2101749770.5287959930.6904891041.691710220.5026562610.7868054430.62891656-0.509683832.1814861720.4834002951.1545049580.673670590.70036051.1648247420.267074489-0.490467688-0.598621359
1832400.9616044-0.234997199-0.5184167573.12359126-0.1091371120.1221997960.4288097430.095566217-0.3347800040.070093316-0.2181425620.6096646990.283009696-0.191565291-0.223425665-0.4252344190.504341884-0.214059801-0.000287823-0.157298089-0.741034934-0.210416375-0.973506723
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10060 is not tested in classification assay
Integrated Annotations for CG10060 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
G-protein coupled receptor signaling pathwayGO:0007186inferred from sequence or structural similarity with UniProtKB:P41776
asymmetric protein localization involved in cell fate determination
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
heterotrimeric G-protein complexGO:0005834inferred from sequence or structural similarity with UniProtKB:P41776
cell cortex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
GTPase activityGO:0003924inferred from sequence or structural similarity with UniProtKB:P41776
GTPase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10060 in FlyBase
FLIGHTClick here to see CG10060 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10060 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10060
Entrez GeneEntrez Gene page for CG10060
UniprotUniprot page for CG10060

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)