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Gene Page - CG Number : CG10076
Gene Summary - CG10076:

CG10076: The gene spire is referred to in FlyBase by the symbol Dmel\spir (CG10076, FBgn0003475). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule binding. There is experimental evidence that it is involved in the biological process: chorion-containing eggshell formation; actin filament-based process; actin nucleation; regulation of cytoskeleton organization; pole plasm assembly; actin filament organization; pole plasm RNA localization; karyosome formation. 54 alleles are reported. The phenotypes of these alleles are annotated with: karyosome; egg chamber; oocyte nucleus. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: KIND; WH2 domain; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages.

Gene summary for CG10076 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10076:CG10076 is perturbed in following parameters in primary screen: NuSize
CG10076 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10076.
Cell Count:
CG_NumberCategoryR1R2R3
CG10076Primary screen696895324
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10076:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181238-0.4888310860.7144689531.8943590880.1367821410.162049425-0.3318179750.883221204-1.035587239-0.435030104-0.1239769150.2362640040.40061502-0.250618663-0.025591757-0.0453867620.715080145-0.076900733-0.241725282-0.417438120.1560995274.3673733844.5000037341.864278758
182784.2355155520.313024594-0.3489275240.6503354730.3831921481.0024761960.6334442581.1321937681.7168548141.4692188340.32900615-0.4971475921.3589090950.7891080511.6177584850.2788200441.1218912112.1234813141.4226246671.988468678-0.1033228883.913684333.673434291
1832280.179273894-0.23108109-0.2772633260.29297373-0.287522792-0.499261239-0.642450424-0.675367309-0.4337492691.536501182-0.657347821-0.0227443290.4100737270.394795377-0.114212171-0.656708282-0.3960670330.017967254-0.607257705-0.38040260.1896494790.13856404-0.843976827
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10076 is not tested in classification assay
Integrated Annotations for CG10076 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
pole plasm RNA localizationGO:0007316inferred from mutant phenotype
pole plasm assembly
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cell cortexGO:0005938inferred from direct assay
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
microtubule bindingGO:0008017inferred from mutant phenotype
actin binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10076 in FlyBase
FLIGHTClick here to see CG10076 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10076 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10076
Entrez GeneEntrez Gene page for CG10076
UniprotUniprot page for CG10076

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)