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Gene Page - CG Number : CG10079
Gene Summary - CG10079:

CG10079: The gene Epidermal growth factor receptor is referred to in FlyBase by the symbol Dmel\Egfr (CG10079, FBgn0003731). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: epidermal growth factor-activated receptor activity. There is experimental evidence for 49 unique biological process terms, many of which group under: system development; biological regulation; sensory organ development; post-embryonic organ morphogenesis; digestive tract development; ovarian follicle cell development; appendage development; cell fate commitment; multicellular organism reproduction; instar larval or pupal morphogenesis. 168 alleles are reported. The phenotypes of these alleles are annotated with 235 unique terms, many of which group under: organ system subdivision; organ system; larval abdominal segment; adult segment; imaginal precursor; external compound sense organ; hypodermal muscle of larval abdomen; non-connected developing system; ventral nerve cord primordium; A1-7 ventral acute muscle 2. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: 14-3-3 domain; 14-3-3 protein; 14-3-3 protein, conserved site; EGF receptor, L domain; Furin-like cysteine-rich domain; Furin-like repeat; Growth factor, receptor; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages.

Gene summary for CG10079 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10079:CG10079 is not perturbed in primary screen.
CG10079 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10079.
Cell Count:
CG_NumberCategoryR1R2R3
CG10079Primary screen448822351
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10079:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181240-0.104353879-0.34522783-0.258170596-0.0217637520.3580020370.8406624740.5626666490.8220295920.866713471-0.522759076-0.932643195-0.818859516-0.6332827660.02706119-0.1095228140.555392751-0.985266177-0.93583925-1.2781812520.6734056351.489225642-0.6502155171.010703174
182760.1162669660.296367698-0.2396655810.4944835890.3355151030.4461480.1948908210.6105930741.3483997570.548479528-0.048957725-0.6203041420.494852822-0.0352816661.1111393620.0644427140.7849647391.6886533991.2076649110.8568952290.050781361-0.445340988-0.317680164
183226-0.0071664330.3719438780.2531357190.315761536-0.428703922-0.475872106-0.754227474-0.557422311-0.818029352-1.01349170.2880891270.286620436-0.517330419-1.0321582181.7950247970.244318681-0.615629432-0.809037009-0.147435708-0.7129085211.5197065890.813907103-0.434630998
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10079 is not tested in classification assay
Integrated Annotations for CG10079 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dorsal appendage formationGO:0046843inferred from mutant phenotype
border follicle cell migration
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886traceable author statement
integral to plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
epidermal growth factor-activated receptor activityGO:0005006inferred from sequence or structural similarity
epidermal growth factor-activated receptor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10079 in FlyBase
FLIGHTClick here to see CG10079 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10079 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10079
Entrez GeneEntrez Gene page for CG10079
UniprotUniprot page for CG10079

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)