Gene Page - CG Number : CG10107

Gene Summary - CG10107:

CG10107: The gene veloren is referred to in FlyBase by the symbol Dmel\velo (CG10107, FBgn0035713). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: SUMO-specific protease activity; cysteine-type peptidase activity. There is experimental evidence that it is involved in the biological process: negative regulation of cell death; axon guidance; dendritic spine morphogenesis; central nervous system projection neuron axonogenesis. 12 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Peptidase C48, SUMO/Sentrin/Ubl1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10107 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10107:

CG10107 is perturbed in following parameters in primary screen: Tint3 Tint4 Tmph2
CG10107 is not tested in classification assay (fluid).
CG10107 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint4- Tmph1-

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10107.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10107	Primary screen	284	587	476
CG10107	Secondary assay	920	1021	889

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10107:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
18	1	266	0.042550719	0.584200112	0.556926313	0.762760776	-0.306452188	-0.303129417	-0.502331721	-0.498201978	2.56979171	11.43227271	4.988254479	1.836751815	4.545436665	3.050473124	14.68870254	4.417301661	16.44022714	8.844789388	26.36835498	3.64239337	0.085925921	-0.918146244	-0.140215101
18	2	50	1.230210782	0.578042062	0.219166741	-0.59671605	0.379789563	-0.606354603	-0.728922341	-0.601653594	0.475522704	2.570560483	1.653565061	-0.009185535	0.26410024	-0.035969827	1.637192602	0.227844306	1.438752294	4.752934152	1.521424572	0.176080004	0.018062284	0.98907631	1.013181792
18	3	200	-0.619128952	-0.172902958	0.542193449	-0.49055158	0.115119835	-0.16064337	0.118899289	-0.146303089	1.157483455	3.206703109	3.234136504	-0.467479908	0.467374764	1.072547931	1.093734261	0.783794647	1.892162491	2.90613098	2.565826396	1.218047816	0.065111063	-0.161451624	0.560481616

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

Transferrin:

CG_Number	Slide No.	ttest P-value	Ratio 1	Ratio 2	Ratio 3
CG10107	Slide1F	0.187	1.113	1.019	1.145
CG10107	Slide1O	0.998	1.100	0.896	1.005
CG10107	Slide1T	0.302	1.023	0.589	0.829

F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10107 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
proteolysis	GO:0006508	inferred by curator from GO:0008234 proteolysis

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
-

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
cysteine-type peptidase activity	GO:0008234	inferred from sequence or structural similarity with SGD_LOCUS:ULP2; SGD:S0001293

Other annotations

Database	Link
FlyBase	Click here to see CG10107 in FlyBase
FLIGHT	Click here to see CG10107 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10107 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10107
Entrez Gene	Entrez Gene page for CG10107
Uniprot	Uniprot page for CG10107

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)