Gene Page - CG Number : CG10116

Gene Summary - CG10116:

CG10116: This gene is referred to in FlyBase by the symbol Dmel\CG10116 (FBgn0036367). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: lipoprotein lipase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: lipid metabolic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Lipase; Lipase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes.

Gene summary for CG10116 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10116:

CG10116 is perturbed in following parameters in primary screen: Okt Tint2 Tmph2
CG10116 is not tested in classification assay (fluid).
CG10116 is perturbed in following parameters in classification assay (transferrin): CellSize+(tfr) Fint1+ Fmph2+ Fmph3+ Fnum+ NuCellD-(tfr) NuSize-(tfr) Rto1-(tfr) Rto2-(tfr) Tint4- Tmph3+ Tnum+

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10116.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10116	Primary screen	337	857	446
CG10116	Secondary assay	790	539	570

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10116:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
18	1	268	1.505130082	-0.350610192	-0.644165855	0.325187072	-0.076765179	-0.218864993	-1.107490683	-0.590008812	0.547306092	2.466417221	2.742773292	-0.22949598	0.597575209	0.777199284	4.242546025	-0.118092088	2.49973442	3.382448168	2.110157636	0.489862526	1.815644444	3.940757031	0.593448103
18	2	48	-0.165359613	-0.727568669	-0.777618691	-0.383348818	0.569866824	0.715672271	0.122690767	0.713364501	1.989465187	4.791776833	3.365031347	0.476236616	0.7965431	0.715624684	3.916240182	0.435882519	6.04702322	5.242102338	3.575025519	1.641703682	0.929096344	-0.284169487	-0.122202622
18	3	198	1.068976911	-0.592571141	-0.385209291	0.066297623	-0.479907697	-1.09614966	-0.759042206	-1.019610636	-0.462101637	1.323618784	0.527284771	0.970775717	-0.007065314	0.434642639	4.405309263	-0.373213436	0.188294351	-0.368911742	0.129209558	-0.357562005	0.025779872	1.005279655	-0.732063894

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

Transferrin:

CG_Number	Slide No.	ttest P-value	Ratio 1	Ratio 2	Ratio 3
CG10116	Slide10F	0.038	1.281	1.178	1.110
CG10116	Slide10O	0.133	1.254	1.184	1.708
CG10116	Slide10T	0.209	1.523	1.047	1.210

F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10116 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
lipid metabolic process	GO:0006629	inferred from electronic annotation with InterPro:IPR000734

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
-

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
lipoprotein lipase activity	GO:0004465	inferred from sequence or structural similarity with UniProtKB:P11153

Other annotations

Database	Link
FlyBase	Click here to see CG10116 in FlyBase
FLIGHT	Click here to see CG10116 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10116 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10116
Entrez Gene	Entrez Gene page for CG10116
Uniprot	Uniprot page for CG10116

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)