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Gene Page - CG Number : CG10118
Gene Summary - CG10118:

CG10118: The gene pale is referred to in FlyBase by the symbol Dmel\ple (CG10118, FBgn0005626). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: tyrosine 3-monooxygenase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; pigmentation; organonitrogen compound metabolic process; regulation of developmental process; response to stimulus; response to temperature stimulus; multicellular organismal development; reproductive behavior; cuticle development; response to stress; multi-organism reproductive process; locomotory behavior; system development. 34 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; organ system subdivision; acellular anatomical structure; adult segment; multicellular structure; adult; cephalopharyngeal skeleton; thoracic segment; sense organ; tracheal system; adult cuticle; spiracle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Aromatic amino acid hydroxylase; Aromatic amino acid hydroxylase, C-terminal; Aromatic amino acid hydroxylase, iron/copper binding site; Tyrosine 3-monooxygenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period.

Gene summary for CG10118 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10118:CG10118 is not perturbed in primary screen.
CG10118 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10118.
Cell Count:
CG_NumberCategoryR1R2R3
CG10118Primary screen419930547
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10118:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181270-0.743236701-0.629404708-0.707697021-0.5817690840.6053502960.5420440380.0177184410.4679208150.395607091-0.3900483490.064025449-0.4918543030.236119979-0.9697968270.733939087-0.411328351-0.116264874-0.092972632-0.211452040.3364477362.0367876161.3054686371.107375675
182460.475871264-0.067987429-0.350545655-0.1635571340.3193625451.2329721.0354920981.3733994892.3666456311.8254191441.0380229381.3205006471.2421608140.5083250250.0328114750.1036558351.1654233482.742754491.5587903592.0094425420.4659939692.7464680161.620926386
1831960.5993356370.616168987-0.675462895-0.3493111580.4098399760.5648218750.2457501680.62916370.6707824961.5148906291.523601836-0.7120335231.0746721161.00804910.492036019-0.0947525971.5028770380.0635414660.8001455850.7053010190.313827334-0.2882146691.475919065
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10118 is not tested in classification assay
Integrated Annotations for CG10118 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of dopamine metabolic processGO:0042053non-traceable author statement
catecholamine metabolic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cellular_componentGO:0005575no biological data available
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
tyrosine 3-monooxygenase activityGO:0004511inferred from sequence or structural similarity with MGD:Th; MGI:MGI:98735
tyrosine 3-monooxygenase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10118 in FlyBase
FLIGHTClick here to see CG10118 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10118 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10118
Entrez GeneEntrez Gene page for CG10118
UniprotUniprot page for CG10118

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)