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Gene Page - CG Number : CG10119
Gene Summary - CG10119:

CG10119: The gene Lamin C is referred to in FlyBase by the symbol Dmel\LamC (CG10119, FBgn0010397). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: structural molecule activity. There is experimental evidence that it is involved in the biological process: muscle tissue morphogenesis; nuclear pore distribution; chromatin silencing; regulation of actin filament polymerization. 43 alleles are reported. The phenotypes of these alleles are annotated with: metathoracic tarsal segment; metathoracic femur; embryonic/larval salivary gland; metathoracic metatarsus; mesothoracic tergum; imaginal disc; metathoracic tibia; ventral thoracic disc; nucleus; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Filament; Intermediate filament protein; Lamin Tail Domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages.

Gene summary for CG10119 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10119:CG10119 is not perturbed in primary screen.
CG10119 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10119.
Cell Count:
CG_NumberCategoryR1R2R3
CG10119Primary screen277876471
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10119:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1812710.372056558-0.386897828-0.156500883-0.7415493-0.454381513-0.623057015-1.37141676-0.7648506080.1988991123.5693794142.277163329-0.4114455440.6212899940.618478030.860112649-0.5820326511.5828625513.0398783142.127455350.1125285630.222116839-0.079819981-0.536065968
18215-0.174485522-0.125278290.089735968-0.7773687390.5950967530.8527894480.509362040.7912849610.2683384270.0358269660.32288771-0.0517099680.361290977-0.0139939331.5153743150.7846244360.200177418-0.3319300740.6237518270.3407519720.5260633520.8828176010.222652674
183165-0.589449351-0.5136338230.121523594-0.3989375950.1063585950.040219938-0.2190230110.057692083-0.2096852772.358297854-0.419020167-0.735175578-0.537791218-0.8493482071.1706190510.767934117-0.7499645-0.585279598-0.499849744-0.212478076-0.366112355-0.0887582881.098413986
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10119 is not tested in classification assay
Integrated Annotations for CG10119 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mitotic nuclear envelope reassemblyGO:0007084inferred from sequence or structural similarity with EMBL:D50080; protein_id:BAA08784
nuclear pore distribution
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
lamin filamentGO:0005638non-traceable author statement
lamin filament
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
structural molecule activityGO:0005198inferred from electronic annotation with InterPro:IPR001664
Other annotations
DatabaseLink
FlyBaseClick here to see CG10119 in FlyBase
FLIGHTClick here to see CG10119 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10119 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10119
Entrez GeneEntrez Gene page for CG10119
UniprotUniprot page for CG10119

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)