Gene Page - CG Number : CG10119

Gene Summary - CG10119:

CG10119: The gene Lamin C is referred to in FlyBase by the symbol Dmel\LamC (CG10119, FBgn0010397). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: structural molecule activity. There is experimental evidence that it is involved in the biological process: muscle tissue morphogenesis; nuclear pore distribution; chromatin silencing; regulation of actin filament polymerization. 43 alleles are reported. The phenotypes of these alleles are annotated with: metathoracic tarsal segment; metathoracic femur; embryonic/larval salivary gland; metathoracic metatarsus; mesothoracic tergum; imaginal disc; metathoracic tibia; ventral thoracic disc; nucleus; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Filament; Intermediate filament protein; Lamin Tail Domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages.

Gene summary for CG10119 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10119:

CG10119 is not perturbed in primary screen.
CG10119 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10119.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10119	Primary screen	277	876	471

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10119:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
18	1	271	0.372056558	-0.386897828	-0.156500883	-0.7415493	-0.454381513	-0.623057015	-1.37141676	-0.764850608	0.198899112	3.569379414	2.277163329	-0.411445544	0.621289994	0.61847803	0.860112649	-0.582032651	1.582862551	3.039878314	2.12745535	0.112528563	0.222116839	-0.079819981	-0.536065968
18	2	15	-0.174485522	-0.12527829	0.089735968	-0.777368739	0.595096753	0.852789448	0.50936204	0.791284961	0.268338427	0.035826966	0.32288771	-0.051709968	0.361290977	-0.013993933	1.515374315	0.784624436	0.200177418	-0.331930074	0.623751827	0.340751972	0.526063352	0.882817601	0.222652674
18	3	165	-0.589449351	-0.513633823	0.121523594	-0.398937595	0.106358595	0.040219938	-0.219023011	0.057692083	-0.209685277	2.358297854	-0.419020167	-0.735175578	-0.537791218	-0.849348207	1.170619051	0.767934117	-0.7499645	-0.585279598	-0.499849744	-0.212478076	-0.366112355	-0.088758288	1.098413986

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10119 is not tested in classification assay

Integrated Annotations for CG10119 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
mitotic nuclear envelope reassembly	GO:0007084	inferred from sequence or structural similarity with EMBL:D50080; protein_id:BAA08784 nuclear pore distribution

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
lamin filament	GO:0005638	non-traceable author statement lamin filament

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
structural molecule activity	GO:0005198	inferred from electronic annotation with InterPro:IPR001664

Other annotations

Database	Link
FlyBase	Click here to see CG10119 in FlyBase
FLIGHT	Click here to see CG10119 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10119 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10119
Entrez Gene	Entrez Gene page for CG10119
Uniprot	Uniprot page for CG10119

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)