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Gene Page - CG Number : CG10120
Gene Summary - CG10120:

CG10120: The gene Malic enzyme is referred to in FlyBase by the symbol Dmel\Men (CG10120, FBgn0002719). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. There is experimental evidence that it is involved in the biological process: regulation of cell death; determination of adult lifespan. 87 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Malic enzyme, N-terminal; Malic enzyme, NAD-binding; Malic enzyme, conserved site; Malic oxidoreductase; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.

Gene summary for CG10120 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10120:CG10120 is not perturbed in primary screen.
CG10120 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10120.
Cell Count:
CG_NumberCategoryR1R2R3
CG10120Primary screen544937525
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10120:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
181272-0.655440294-0.0549132150.228718496-0.268735937-0.179156061-1.63588878-0.533751575-2.031691809-0.4721361720.7215096371.3237607330.0731643731.266272610.371024815-0.3129739710.0498406130.5499018390.6823192221.057109682-0.6767389172.2777484551.4847116231.354755495
182141.1015193960.3597057310.2244538880.8557794360.7523391621.0513837230.8382617921.1111875111.0767262590.3913586221.4178656460.390832371-0.162783712-0.3047418692.2754345720.4125286350.2548668481.4603717170.5050529981.0531503642.8882521680.048463175-0.327082703
1831641.1243556810.795230639-0.386778963-0.7045708120.7546904290.7404086580.5342999590.6456922970.9587893561.686076690.969453085-0.4037510320.4871598050.5376655070.9763880110.1516400990.7378374720.7544592540.951940281.21263933-0.1312306370.213659339-0.076785502
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10120 is not tested in classification assay
Integrated Annotations for CG10120 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of cell deathGO:0010941inferred from mutant phenotype
oxidation-reduction process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activityGO:0004473inferred from direct assay
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10120 in FlyBase
FLIGHTClick here to see CG10120 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10120 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10120
Entrez GeneEntrez Gene page for CG10120
UniprotUniprot page for CG10120

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)