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Gene Page - CG Number : CG10130
Gene Summary - CG10130:

CG10130: The gene Sec61β is referred to in FlyBase by the symbol Dmel\Sec61β (CG10130, FBgn0010638). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein transporter activity. There is experimental evidence that it is involved in the biological process: neuron projection morphogenesis; negative regulation of autophagy. 16 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; leg; chorion; embryonic/larval trachea; egg; dorsal appendage; denticle belt. It has one annotated transcript and one annotated polypeptide. Protein features are: Preprotein translocase Sec, Sec61-beta subunit; Preprotein translocase Sec, Sec61-beta subunit, eukarya. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10130 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10130:CG10130 is not perturbed in primary screen.
CG10130 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10130.
Cell Count:
CG10130Primary screen396793463
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10130:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10130 is not tested in classification assay
Integrated Annotations for CG10130 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
SRP-dependent cotranslational protein targeting to membrane, translocationGO:0006616inferred from sequence or structural similarity with UniProtKB:P38391
negative regulation of autophagy
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Sec61 translocon complexGO:0005784non-traceable author statement
Sec61 translocon complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein transporter activityGO:0008565inferred from sequence or structural similarity with UniProtKB:P38391
Other annotations
FlyBaseClick here to see CG10130 in FlyBase
FLIGHTClick here to see CG10130 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10130 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10130
Entrez GeneEntrez Gene page for CG10130
UniprotUniprot page for CG10130

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)