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Gene Page - CG Number : CG10161
Gene Summary - CG10161:

CG10161: The gene Eukaryotic initiation factor 3 p66 subunit is referred to in FlyBase by the symbol Dmel\eIF-3p66 (CG10161, FBgn0040227). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: regulation of translational initiation. 4 alleles are reported. The phenotype of these alleles is annotated with: eye. It has one annotated transcript and one annotated polypeptide. Protein features are: Eukaryotic translation initiation factor 3, subunit 7. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages.

Gene summary for CG10161 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10161:CG10161 is perturbed in following parameters in primary screen: Fint2 Fint3
CG10161 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc+ LP_Fint1+ LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fmph1+ LP_Fmph2+ LP_Fmph3+ LP_Fnum+ NuCirc+(fld) NuCirc-(fld) NuFluct+(fld) NuFluct-(fld) NuSize-(fld) Okt-(fld) Rto1+ Rto2+ Rto2+ Rto3+ Rto3+ SP_Fclc+ SP_Fint1+ SP_Fint1+ SP_Fint2+ SP_Fint2+ SP_Fint3+ SP_Fmph1+ SP_Fmph2+ SP_Fmph3+ SP_Fnum+
CG10161 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10161.
Cell Count:
CG_NumberCategoryR1R2R3
CG10161Primary screen255584509
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10161:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1812971.1601524783.6043205833.131110713-0.549704739-0.912256405-2.323584648-0.554110758-3.15665132-1.8160514351.9649696520.5075940313.752294141-0.185419139-1.6823139682.701824573-0.789031676-0.7564300921.809141525-0.79070019-1.779038039-0.232767271-0.443408126-0.337422338
182192.3085726734.1579409824.2514288860.700813486-0.700741597-3.9795077470.314831086-5.892986549-2.949137471.311211601-0.0960131110.6066325081.0761071171.49216881-0.908442289-0.339513896-0.420062767-0.829856186-0.540369649-0.835341421-0.6512328352.7136484833.056713692
1831691.6235723951.1124915250.819414911.338056701-0.320771735-1.213692006-0.142161276-1.410842640.677599668-0.2899895940.3668460461.2829760970.865952466-0.232616852.790435603-0.0383212321.8424732661.5439848821.7062552950.5254268110.5459744321.818543992-0.633203934
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10161Slide14C0.0301.9161.3931.750
CG10161Slide14O0.0310.8690.7100.747
CG10161Slide14P0.0172.8032.5552.026
CG10161Slide4C0.3630.8930.8470.925
CG10161Slide4O0.7601.1741.0790.862
CG10161Slide4P0.8601.0370.9811.049
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10161 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
translationGO:0006412non-traceable author statement
translational initiation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytosolGO:0005829non-traceable author statement
eukaryotic translation initiation factor 3 complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
translation initiation factor activityGO:0003743non-traceable author statement
translation initiation factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10161 in FlyBase
FLIGHTClick here to see CG10161 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10161 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10161
Entrez GeneEntrez Gene page for CG10161
UniprotUniprot page for CG10161

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)