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Gene Page - CG Number : CG1017
Gene Summary - CG1017:

CG1017: The gene Microfibril-associated protein 1 is referred to in FlyBase by the symbol Dmel\Mfap1 (CG1017, FBgn0035294). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: mRNA splicing, via spliceosome; regulation of G2/M transition of mitotic cell cycle; neurogenesis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Micro-fibrillar-associated protein 1, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG1017 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1017:CG1017 is perturbed in following parameters in primary screen: Fclc Fint3 Fmph1 Fmph2 Fmph3 NuSize Okt Tclc Tint1 Tint2 Tint3 Tint4 Tmph1 Tmph2 Tmph3
CG1017 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc+ LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- LP_Fmph1+ LP_Fmph2+ LP_Fmph3+ LP_Fnum+ NuCellD+(fld) NuCirc+(fld) NuSize-(fld) Okt+(fld) Rto3+ SP_Fclc+ SP_Fint1+ SP_Fint2+ SP_Fint3+ SP_Fint4- SP_Fmph1+ SP_Fmph2+ SP_Fmph3+
CG1017 is perturbed in following parameters in classification assay (transferrin): Rto2+(tfr) Tint1- Tint4- Tmph1-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1017.
Cell Count:
CG1017Primary screen264489457
CG1017Secondary assay924901867
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1017:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1017 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
nuclear mRNA splicing, via spliceosomeGO:0000398inferred from mutant phenotype
regulation of G2/M transition of mitotic cell cycle
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
microfibrilGO:0001527inferred from sequence or structural similarity with UniProtKB:P55080
precatalytic spliceosome
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with Prp38
Other annotations
FlyBaseClick here to see CG1017 in FlyBase
FLIGHTClick here to see CG1017 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1017 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1017
Entrez GeneEntrez Gene page for CG1017
UniprotUniprot page for CG1017

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)