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Gene Page - CG Number : CG10181
Gene Summary - CG10181:

CG10181: The gene Multiple drug resistance 65 is referred to in FlyBase by the symbol Dmel\Mdr65 (CG10181, FBgn0004513). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: drug transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: establishment of blood-brain barrier; response to methotrexate. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: AAA+ ATPase domain; ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.

Gene summary for CG10181 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10181:CG10181 is not perturbed in primary screen.
CG10181 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10181.
Cell Count:
CG10181Primary screen404806506
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10181:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10181 is not tested in classification assay
Integrated Annotations for CG10181 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
response to methotrexateGO:0031427inferred from expression pattern
establishment of blood-brain barrier
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to plasma membraneGO:0005887non-traceable author statement
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
drug transmembrane transporter activityGO:0015238inferred from sequence or structural similarity with UniProtKB:P08183
ATP binding
Other annotations
FlyBaseClick here to see CG10181 in FlyBase
FLIGHTClick here to see CG10181 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10181 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10181
Entrez GeneEntrez Gene page for CG10181
UniprotUniprot page for CG10181

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)