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Gene Page - CG Number : CG10188
Gene Summary - CG10188:

CG10188: This gene is referred to in FlyBase by the symbol Dmel\CG10188 (FBgn0032796). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Rho guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of Rho protein signal transduction. 9 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Dbl homology (DH) domain; Pleckstrin homology domain; Pleckstrin homology-like domain; Rho GTP exchange factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages.

Gene summary for CG10188 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10188:CG10188 is not perturbed in primary screen.
CG10188 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10188.
Cell Count:
CG_NumberCategoryR1R2R3
CG10188Primary screen485720529
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10188:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191160.0680299440.236651251-0.567631543-0.4555912350.4629559770.9906819330.6082089590.981811561.4124762280.6358876410.9007478820.0349597851.5358907161.416308758-0.8105187891.3566229950.668456280.7819288761.4992749831.1981846020.6401309421.7802120440.420360114
192180-0.515576141-0.311364691-0.885373648-0.6651548680.3660602080.3402280170.2319589560.3375831490.8224326420.4780858210.0442852950.2218692711.0748552810.348734477-0.143984191-0.0697126481.1887556891.1930587920.8897745510.5394630881.2686825430.4677680960.408483583
193150-0.7151867030.6370396920.377170148-0.72697450.2233170480.5755925520.1411064420.5021315590.22313576-0.264315604-0.1540598450.012206225-0.045997091-0.13543017-0.177633125-0.296834589-0.5913634320.3641734-0.4671021280.39207327-0.9773865780.2964308020.125005035
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10188 is not tested in classification assay
Integrated Annotations for CG10188 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of Rho protein signal transductionGO:0035023inferred from electronic annotation with InterPro:IPR000219
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
intracellularGO:0005622inferred from electronic annotation with InterPro:IPR000219
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
Rho guanyl-nucleotide exchange factor activityGO:0005089inferred from sequence or structural similarity with EMBL:U73199
phospholipid binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10188 in FlyBase
FLIGHTClick here to see CG10188 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10188 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10188
Entrez GeneEntrez Gene page for CG10188
UniprotUniprot page for CG10188

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)