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Gene Page - CG Number : CG10210
Gene Summary - CG10210:

CG10210: The gene twister is referred to in FlyBase by the symbol Dmel\tst (CG10210, FBgn0039117). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: helicase activity. There is experimental evidence that it is involved in the biological process: regulation of alternative mRNA splicing, via spliceosome. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DSH, C-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, ATP-dependent, SK12/DOB1; rRNA-processing arch domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10210 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10210:CG10210 is not perturbed in primary screen.
CG10210 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10210.
Cell Count:
CG_NumberCategoryR1R2R3
CG10210Primary screen206876341
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10210:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191311.4909666531.0846271430.2991741140.149752466-0.818224935-1.170952703-1.288811836-1.426241049-1.2857589850.8906104791.4767952540.8583261511.0320067760.472660142-0.528173671-1.3637663730.5940310830.5203901480.920441715-1.2538073261.1686892010.4420597793.512144204
1921952.598324682.1664430640.8577805850.2313936781.122760230.3523195370.5565888960.4325010721.0178229410.059175474-0.400788852-0.5500659660.290538791-0.307119041-0.3588989410.5587906970.314398205-0.8196683170.3917226721.0681423181.071074103-0.304773107-0.034475824
193105-0.560591015-0.547174904-0.775544808-0.764736769-0.484723005-1.129420446-1.019613845-1.331927686-0.8863730230.4690440960.34004378-0.344725864-0.965361186-0.6919406940.318465495-0.221334585-1.313681505-0.948088208-1.367167153-0.7224376891.8833662850.241139814-0.247506011
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10210 is not tested in classification assay
Integrated Annotations for CG10210 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of alternative nuclear mRNA splicing, via spliceosomeGO:0000381inferred from mutant phenotype
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred by curator from GO:0000381
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
helicase activityGO:0004386inferred from sequence or structural similarity with SGD_LOCUS:SKI2; SGD:S0004390
helicase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10210 in FlyBase
FLIGHTClick here to see CG10210 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10210 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10210
Entrez GeneEntrez Gene page for CG10210
UniprotUniprot page for CG10210

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)