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Gene Page - CG Number : CG10212
Gene Summary - CG10212:

CG10212: The gene SMC2 is referred to in FlyBase by the symbol Dmel\SMC2 (CG10212, FBgn0027783). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: mitotic chromosome condensation; mitosis; mitotic spindle organization; neurogenesis. 10 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; embryonic/larval brain. It has one annotated transcript and one annotated polypeptide. Protein features are: RecF/RecN/SMC; SMCs flexible hinge; Structural maintenance of chromosomes protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10212 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10212:CG10212 is perturbed in following parameters in primary screen: Tint2 Tint4 Tmph2 Tmph3
CG10212 is not tested in classification assay (fluid).
CG10212 is perturbed in following parameters in classification assay (transferrin): Fmph1+ NuCirc+(tfr) NuFluct-(tfr) NuSize-(tfr) Tmph1- Tmph2- Tmph3-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10212.
Cell Count:
CG_NumberCategoryR1R2R3
CG10212Primary screen456753663
CG10212Secondary assay12008041064
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10212:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
19133-0.6225271910.2818416760.3595024810.5939401320.3104916720.453130063-0.5584904720.0596545561.7414875716.6956493425.0789648890.9583781492.5286069542.3171760752.9032012820.4407402426.7849529575.5408085217.7303143221.6314068145.3021833070.9888223641.124922853
192193-0.108535183-0.2381005470.660562664-0.0738082660.0452306232.2520356542.7484668661.533820332.3055847062.8559740643.111982312-0.5646093740.8217375950.5858439373.1645238930.0048822732.1847916035.2719382213.2545506852.6898214380.239711092-0.199023337-0.29267463
1931030.6232000290.47333932-0.1052810370.3145798871.4847150861.7559765971.4205914611.8633541.8863447091.8748482822.7015536750.1485156980.4251085191.0077135760.9196930190.7018141231.128842641.6906417981.2841391832.0328901180.920963109-0.4913773850.97605091
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10212Slide1F0.1991.1611.0581.046
CG10212Slide1O0.3020.9771.1361.101
CG10212Slide1T0.4910.8620.8031.089
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10212 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
sister chromatid cohesionGO:0007062inferred from sequence or structural similarity with SGD_LOCUS:SMC2; SGD:S0001927
mitotic spindle organization
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
condensin complexGO:0000796non-traceable author statement
cohesin complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677inferred from sequence or structural similarity with SGD_LOCUS:SMC2; SGD:S0001927
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10212 in FlyBase
FLIGHTClick here to see CG10212 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10212 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10212
Entrez GeneEntrez Gene page for CG10212
UniprotUniprot page for CG10212

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)