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Gene Page - CG Number : CG10226
Gene Summary - CG10226:

CG10226: This gene is referred to in FlyBase by the symbol Dmel\CG10226 (FBgn0035695). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled; drug transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: response to methotrexate. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.

Gene summary for CG10226 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10226:CG10226 is not perturbed in primary screen.
CG10226 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10226.
Cell Count:
CG_NumberCategoryR1R2R3
CG10226Primary screen598181425
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10226:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191440.8054289420.1288660040.322755793-0.0974442961.0869442611.1066415811.2645093750.8002354151.3579824581.3227130830.7303561750.72841811.1337313621.3943054260.2976216330.6994788742.2634323180.7260619052.3205297611.4421772941.43239326-0.266185168-0.347328713
1921820.164153564-0.756345389-0.516477837-1.007948647-2.14263701-5.883969016-3.842388543-6.335747911-4.73930977-1.98440098-1.6658541481.476921053-1.091018922-1.6652553751.386617136-1.379729566-0.495132048-0.068978795-2.000106482-4.4070838251.3505961590.8343230650.40112974
19392-0.1774346271.3443781322.130174524-1.0594649760.9840769161.5206012731.9639688891.2436867520.7891428671.5302079020.200954166-0.664594619-0.0507468440.205530480.65287896-0.139188294-0.171624355-0.2056876480.1139110041.49092028-0.8830998313.4539202071.156672344
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10226 is not tested in classification assay
Integrated Annotations for CG10226 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
drug transportGO:0015893inferred from sequence or structural similarity with MGD:Abcb1a; MGI:MGI:97570
response to methotrexate
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to membraneGO:0016021inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ATPase activity, coupledGO:0042623inferred from sequence or structural similarity with MGD:Abcb1a; MGI:MGI:97570
drug transmembrane transporter activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10226 in FlyBase
FLIGHTClick here to see CG10226 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10226 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10226
Entrez GeneEntrez Gene page for CG10226
UniprotUniprot page for CG10226

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)