Gene Page - CG Number : CG10229

Gene Summary - CG10229:

CG10229: The gene Katanin 60 is referred to in FlyBase by the symbol Dmel\Kat60 (CG10229, FBgn0040208). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule-severing ATPase activity. There is experimental evidence that it is involved in the biological process: chaeta development; wing disc development; plus-end specific microtubule depolymerization; negative regulation of cell migration; microtubule depolymerization; cytoplasmic microtubule organization; mitotic anaphase A; mitotic sister chromatid segregation; microtubule severing. 11 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; Kenyon cell; mushroom body alpha-lobe. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Vps4 oligomerisation, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10229 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10229:

CG10229 is not perturbed in primary screen.
CG10229 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10229.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10229	Primary screen	495	788	584

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10229:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
19	1	46	-0.27999286	-0.274700678	-0.468372876	-0.276737483	0.705005414	1.147503175	1.253272263	1.201822212	1.492752977	-0.406409148	1.018274635	-0.516071434	0.112842874	0.564404313	-0.340967226	0.634578884	-0.489176409	0.162070854	-0.639308057	1.584569839	0.260867985	-0.15015734	0.468131673
19	2	210	-0.268808297	-0.27236818	-0.469895985	-0.499256332	0.310739113	0.723773661	0.515012177	0.727176945	0.975857763	-1.358923547	-0.165903079	2.309665496	0.761674745	0.616208767	4.450426285	0.048657554	-0.727591858	-0.505721793	-0.826081975	0.67809938	2.304920799	1.902235746	1.840835227
19	3	120	-0.080844304	0.543275509	0.741675928	2.657154371	1.509839251	2.650037596	2.314362527	2.286529451	1.502788208	1.404510022	0.947909734	0.082013189	0.690944103	0.700450442	1.296029521	0.135954603	2.699037006	0.378007832	1.188277538	1.930963087	0.346654203	-0.563105355	-0.329800586

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10229 is not tested in classification assay

Integrated Annotations for CG10229 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
microtubule severing	GO:0051013	non-traceable author statement microtubule severing

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
katanin complex	GO:0008352	non-traceable author statement katanin complex

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
protein binding	GO:0005515	inferred from physical interaction with Myo10A microtubule binding

Other annotations

Database	Link
FlyBase	Click here to see CG10229 in FlyBase
FLIGHT	Click here to see CG10229 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10229 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10229
Entrez Gene	Entrez Gene page for CG10229
Uniprot	Uniprot page for CG10229

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)