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Gene Page - CG Number : CG10229
Gene Summary - CG10229:

CG10229: The gene Katanin 60 is referred to in FlyBase by the symbol Dmel\Kat60 (CG10229, FBgn0040208). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule-severing ATPase activity. There is experimental evidence that it is involved in the biological process: chaeta development; wing disc development; plus-end specific microtubule depolymerization; negative regulation of cell migration; microtubule depolymerization; cytoplasmic microtubule organization; mitotic anaphase A; mitotic sister chromatid segregation; microtubule severing. 11 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; Kenyon cell; mushroom body alpha-lobe. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Vps4 oligomerisation, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10229 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10229:CG10229 is not perturbed in primary screen.
CG10229 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10229.
Cell Count:
CG_NumberCategoryR1R2R3
CG10229Primary screen495788584
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10229:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
19146-0.27999286-0.274700678-0.468372876-0.2767374830.7050054141.1475031751.2532722631.2018222121.492752977-0.4064091481.018274635-0.5160714340.1128428740.564404313-0.3409672260.634578884-0.4891764090.162070854-0.6393080571.5845698390.260867985-0.150157340.468131673
192210-0.268808297-0.27236818-0.469895985-0.4992563320.3107391130.7237736610.5150121770.7271769450.975857763-1.358923547-0.1659030792.3096654960.7616747450.6162087674.4504262850.048657554-0.727591858-0.505721793-0.8260819750.678099382.3049207991.9022357461.840835227
193120-0.0808443040.5432755090.7416759282.6571543711.5098392512.6500375962.3143625272.2865294511.5027882081.4045100220.9479097340.0820131890.6909441030.7004504421.2960295210.1359546032.6990370060.3780078321.1882775381.9309630870.346654203-0.563105355-0.329800586
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10229 is not tested in classification assay
Integrated Annotations for CG10229 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
microtubule severingGO:0051013non-traceable author statement
microtubule severing
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
katanin complexGO:0008352non-traceable author statement
katanin complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with Myo10A
microtubule binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10229 in FlyBase
FLIGHTClick here to see CG10229 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10229 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10229
Entrez GeneEntrez Gene page for CG10229
UniprotUniprot page for CG10229

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)