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Gene Page - CG Number : CG10234
Gene Summary - CG10234:

CG10234: The gene Heparan sulfate 2-O-sulfotransferase is referred to in FlyBase by the symbol Dmel\Hs2st (CG10234, FBgn0024230). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: heparan sulfate 2-O-sulfotransferase activity. There is experimental evidence that it is involved in the biological process: open tracheal system development. 5 alleles are reported. The phenotypes of these alleles are annotated with: dorsal branch; presumptive embryonic/larval tracheal system. It has one annotated transcript and one annotated polypeptide. Protein features are: Heparan sulphate 2-O-sulfotransferase; Sulfotransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, in adult female stages.

Gene summary for CG10234 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10234:CG10234 is not perturbed in primary screen.
CG10234 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc- LP_Fint2- LP_Fint3- LP_Fmph1- LP_Fmph2- LP_Fmph3- LP_Fnum- NuSize-(fld) Okt+(fld) Rto1+ Rto2+ Rto3+ SP_Fclc- SP_Fint4- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10234 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10234.
Cell Count:
CG_NumberCategoryR1R2R3
CG10234Primary screen204965617
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10234:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191520.066351308-0.109454458-0.383278223-0.444372076-1.497741181-2.433395159-2.151048336-2.900474473-2.537883732-0.050908814-0.629189007-0.842612734-1.166382283-1.31519717-0.688426984-1.350118973-0.957477859-0.552547975-0.821638312-2.4677012581.624573517-0.665439565-0.388610852
1922041.3295088370.5512514891.7537428351.2333619361.6388702153.8205581495.5282501592.9846325483.050647766-0.500813190.4513552530.3188530931.3404413070.56749089-0.0115939350.1374436211.3310308851.7630186851.1815628313.3349310641.2027889934.3020299068.245773159
1931141.4748045381.3117195851.3576616030.5657776121.9521635072.4534857072.777760712.1680682851.6418986770.2737077310.543864289-0.1115111930.3562215380.1346680880.1669350470.1836570641.5636018960.4918033710.8891664652.3187166440.6458375960.219639639-0.336253936
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10234Slide4C0.0010.7720.7530.749
CG10234Slide4O0.0021.3721.3671.280
CG10234Slide4P0.2530.8790.9620.917
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10234 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
signal transductionGO:0007165non-traceable author statement
open tracheal system development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to membraneGO:0016021inferred from electronic annotation with InterPro:IPR005331, InterPro:IPR007734
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
heparan sulfate 2-O-sulfotransferase activityGO:0004394inferred from sequence or structural similarity with EMBL:AF060178
heparan sulfate 2-O-sulfotransferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10234 in FlyBase
FLIGHTClick here to see CG10234 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10234 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10234
Entrez GeneEntrez Gene page for CG10234
UniprotUniprot page for CG10234

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)