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Gene Page - CG Number : CG10263
Gene Summary - CG10263:

CG10263: The gene Hakai is referred to in FlyBase by the symbol Dmel\Hakai (CG10263, FBgn0032812). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cadherin binding. There is experimental evidence that it is involved in the biological process: dorsal closure; chitin-based cuticle development; segmentation; head involution; midgut development; actin filament organization; epithelium development; epithelial cell migration, open tracheal system; protein ubiquitination. 4 alleles are reported. The phenotypes of these alleles are annotated with: leg; wing. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.

Gene summary for CG10263 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10263:CG10263 is not perturbed in primary screen.
CG10263 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10263.
Cell Count:
CG_NumberCategoryR1R2R3
CG10263Primary screen521673528
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10263:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191741.107526366-0.2279734660.097950193-0.4036920.5891246220.6142607130.8000526040.3452383571.1899581960.7195903341.093890245-0.2497433360.8974567120.282138191-0.0069800060.08678602-0.4876408560.47886931-0.6935016590.942707578-0.1652658510.9434980171.076078503
1922120.9337865980.372854952-0.3912670360.327424791-0.276288971-0.375190294-0.790897491-0.342902679-0.815654101-0.013539482-0.218961179-0.834770751-0.4017936420.0163428591.36622949-0.021937527-0.904084465-0.59445442-1.031271741-0.919393338-0.2757127840.9262152350.34991574
19362-0.293167446-0.100676915-0.6259443220.4758429141.6794983231.0520970620.7316416310.7847043351.3526374071.3878052891.2094234190.9505323020.482319660.5352907360.1577154530.7986687571.422930141.7124281151.1546279611.6823246020.6704519060.0675944820.050478368
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10263 is not tested in classification assay
Integrated Annotations for CG10263 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein ubiquitinationGO:0016567inferred from direct assay
dorsal closure
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
perinuclear region of cytoplasmGO:0048471inferred from direct assay
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cadherin bindingGO:0045296inferred from physical interaction with shg
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10263 in FlyBase
FLIGHTClick here to see CG10263 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10263 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10263
Entrez GeneEntrez Gene page for CG10263
UniprotUniprot page for CG10263

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)