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Gene Page - CG Number : CG1030
Gene Summary - CG1030:

CG1030: The gene Sex combs reduced is referred to in FlyBase by the symbol Dmel\Scr (CG1030, FBgn0003339). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; sex comb development. 116 alleles are reported. The phenotypes of these alleles are annotated with 46 unique terms, many of which group under: organ system subdivision; adult segment; thoracic segment; organ system; non-connected developing system; embryonic thoracic segment; larval head segment; appendage segment; external compound sense organ; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox protein, antennapedia type; Homeobox protein, antennapedia type, conserved site; Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, during early pupal stages.

Gene summary for CG1030 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1030:CG1030 is perturbed in following parameters in primary screen: Tclc Tmph2
CG1030 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint4- LP_Fnum- NuSize-(fld) Rto1- Rto2- Rto3- SP_Fnum-
CG1030 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1+ Tint1+ Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1030.
Cell Count:
CG_NumberCategoryR1R2R3
CG1030Primary screen676492170
CG1030Secondary assay908938956
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1030:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1030Slide10C0.1021.2501.6901.255
CG1030Slide10O0.2251.1071.3161.021
CG1030Slide10P0.7100.9111.1690.746
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1030Slide10F0.0221.0741.1741.151
CG1030Slide10O0.6470.9541.0391.068
CG1030Slide10T0.6440.8441.2010.704
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1030 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
segment specificationGO:0007379non-traceable author statement
sex comb development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with UniProtKB:P10628
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with UniProtKB:P10628
sequence-specific DNA binding transcription factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1030 in FlyBase
FLIGHTClick here to see CG1030 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1030 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1030
Entrez GeneEntrez Gene page for CG1030
UniprotUniprot page for CG1030

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)