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Gene Page - CG Number : CG10318
Gene Summary - CG10318:

CG10318: The gene NC2α is referred to in FlyBase by the symbol Dmel\NC2α (CG10318, FBgn0034650). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Histone-fold; Transcription factor CBF/NF-Y/archaeal histone. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10318 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10318:CG10318 is not perturbed in primary screen.
CG10318 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10318.
Cell Count:
CG_NumberCategoryR1R2R3
CG10318Primary screen7280403
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10318:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191103-0.098013174-0.265144762-0.373178471-0.6533177311.0780931380.391593361-0.2933552220.321757420.954805997-0.286786118-0.7645679380.065554724-0.24737761-0.038165175-0.2224228110.4309470410.5602515850.3962348280.9287011250.873946687-0.1067888934.8107518393.059709838
192243-6.779081019-5.662226747-6.330486288-7.536079001-4.681812326-6.50611091-5.067748071-6.656170159-6.191645607-5.102768604-5.432039219-5.928630109-6.931308125-7.438189395-5.718879307-5.532264423-7.445779716-4.850406967-7.423687472-5.74153583-4.415958613-3.533772606-4.303791552
19333-0.0774689971.797105470.251810035-0.4879420620.7184158950.8180660181.0899211750.9923001670.214349498-0.619291620.0626741450.5386368470.038135472-0.518379816-0.614503743-0.710774244-1.607710925-0.260751891-1.7341889020.15533642-0.424594367-0.131186115-0.538387844
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10318 is not tested in classification assay
Integrated Annotations for CG10318 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
negative regulation of RNA polymerase II transcriptional preinitiation complex assemblyGO:0017055non-traceable author statement
negative regulation of transcription from RNA polymerase II promoter
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
negative cofactor 2 complexGO:0017054non-traceable author statement
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assemblyGO:0001075contributes_to inferred from physical interaction with NC2β
transcription factor binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10318 in FlyBase
FLIGHTClick here to see CG10318 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10318 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10318
Entrez GeneEntrez Gene page for CG10318
UniprotUniprot page for CG10318

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)