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Gene Page - CG Number : CG10367
Gene Summary - CG10367:

CG10367: The gene HMG Coenzyme A reductase is referred to in FlyBase by the symbol Dmel\Hmgcr (CG10367, FBgn0263782). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hydroxymethylglutaryl-CoA reductase (NADPH) activity. There is experimental evidence that it is involved in the biological process: locomotory behavior; pole cell migration; germ cell migration; embryonic heart tube development; ecdysis, chitin-based cuticle. 29 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic dorsal vessel; pole cell; embryonic/larval dorsal trunk; germline cell; embryonic/larval tracheal system; cardioblast; embryonic pericardial cell; denticle belt. It has one annotated transcript and one annotated polypeptide. Protein features are: Hydroxymethylglutaryl-CoA reductase, N-terminal; Hydroxymethylglutaryl-CoA reductase, class I/II; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding; Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain; Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site; Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding; Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; Hydroxymethylglutaryl-CoA reductase, metazoan; Sterol-sensing domain. Gene sequence location is 3R:19559046..19576714.

Gene summary for CG10367 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10367:CG10367 is perturbed in following parameters in primary screen: Fmph2
CG10367 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc- LP_Fint1+ LP_Fint2+ LP_Fint3+ NuCellD+(fld) Okt+(fld) Rto2- Rto3- SP_Fmph2- SP_Fnum-
CG10367 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10367.
Cell Count:
CG_NumberCategoryR1R2R3
CG10367Primary screen332119372
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10367:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191136-1.1100170642.3689723143.839362906-0.826050429-1.9574235-0.3682963184.069706598-0.573964126-0.08238053-0.7242639241.6439125130.624569804-0.562508936-0.27810271-0.190652623-1.0784984-0.3898027043.149137571-0.6444581210.7083200430.5002008262.630305787-0.027249366
192300-0.847278266-0.864944521-0.614551616-0.402790262-1.122876276-1.922570935-1.4768745-1.982335171-0.675900745-0.913223194-0.069197242-0.28236408-0.1481556650.255589214-0.299636268-0.776527575-0.1737833950.289233493-0.03390717-0.44778802-1.011119443-0.666445533-1.142581664
193300.345641052-0.1682512840.244936696-0.5067938771.4305134812.8873892844.9484183541.8638365681.38702469-1.542699052-0.316399366-0.03831462-1.578947821-0.569738353-0.330583813-0.845716464-0.624813546-0.455095703-0.6249435051.717705122-0.089159524-0.39947190.153817943
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10367Slide19C0.0521.1481.4651.451
CG10367Slide19O0.0321.3711.2591.459
CG10367Slide19P0.4170.9791.0951.102
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10367 :Gene Ontology Annoations: Biological Process
Gene Ontology Annoations: Cellular Component
Gene Ontology Annoations: Molecular Function
Other annotations
DatabaseLink
FlyBaseClick here to see CG10367 in FlyBase
FLIGHTClick here to see CG10367 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10367 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10367
Entrez GeneEntrez Gene page for CG10367
UniprotUniprot page for CG10367

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)