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Gene Page - CG Number : CG10370
Gene Summary - CG10370:

CG10370: The gene Tat-binding protein-1 is referred to in FlyBase by the symbol Dmel\Tbp-1 (CG10370, FBgn0028684). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: cellular process; proteolysis. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 26S proteasome subunit P45; AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.

Gene summary for CG10370 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10370:CG10370 is perturbed in following parameters in primary screen: Fint1 Fint2 Fmph2 Okt Tclc Tint1 Tint2 Tint3 Tint4 Tmph1 Tmph2 Tmph3 Tnum
CG10370 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc- LP_Fint1- LP_Fint2- LP_Fint3- NuCirc+(fld) NuSize-(fld) Rto1- Rto2- Rto3- SP_Fint1- SP_Fint2- SP_Fint3- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10370 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint1- Fint2- Fint3- Fint4- Fmph1- Fmph2- Fmph3- Fnum- NuSize-(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tclc- Tint1- Tint2- Tint3- Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10370.
Cell Count:
CG_NumberCategoryR1R2R3
CG10370Primary screen460222240
CG10370Secondary assay1047787771
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10370:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1911397.31417890114.6686312215.613957596.2031026933.2324661578.00316486813.2534704913.5546686711.8849452313.424851189.3673186520.497493583.9714053962.89649196222.431386583.3330621918.4809773217.4496221533.977573312.713897541.8182348071.810444526-0.433861065
1922972.4729211341.471749908-0.1622855091.963784645-0.497929866-0.5504540752.33861806-0.695735051.3019702442.9965577531.2054018491.6936943740.8462216190.925944264.6710198690.1450733032.8947703083.3320837053.6578765371.225198587-0.5406456560.081605619-0.360976337
1932712.8905666610.13761371.0631066432.592320439-0.3439375410.2954611164.7591531880.0042727081.926623599.8797441653.6446254851.637154683-0.9012848671.6869370378.4165102046.5260470316.8899233195.5334285926.5883275953.521800016-0.574192443-0.701040116-0.902307255
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10370Slide10C0.0240.8950.7600.807
CG10370Slide10O0.2881.0461.0081.206
CG10370Slide10P0.0010.5030.5490.678
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10370Slide1F0.0000.5770.4700.468
CG10370Slide1O0.1170.9590.8550.900
CG10370Slide1T0.0010.5660.4800.463
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10370 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508inferred from direct assay AND inferred from sequence or structural similarity with HGNC_gene:PSMC3; HGNC:9549; OMIM:186852 AND inferred from sequence or structural similarity with SGD_LOCUS:RPT5; SGD:S0005643
cellular process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
proteasome regulatory particle, base subcomplexGO:0008540non-traceable author statement
proteasome regulatory particle
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175non-traceable author statement
ATPase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10370 in FlyBase
FLIGHTClick here to see CG10370 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10370 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10370
Entrez GeneEntrez Gene page for CG10370
UniprotUniprot page for CG10370

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)