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Gene Page - CG Number : CG10376
Gene Summary - CG10376:

CG10376: This gene is referred to in FlyBase by the symbol Dmel\CG10376 (FBgn0032702). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein serine/threonine phosphatase activity. It is reported to be involved in the biological process: protein dephosphorylation. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein phosphatase 2C; Protein phosphatase 2C-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10376 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10376:CG10376 is perturbed in following parameters in primary screen: Fint3 Fmph2 Tint2 Tint3 Tmph2 Tmph3
CG10376 is perturbed in following parameters in classification assay (fluid): LP_Fint1- LP_Fint2- LP_Fint3- NuCellD+(fld) NuCirc-(fld) NuFluct+(fld) Rto1+ Rto2+ SP_Fint3- SP_Fmph1+ SP_Fmph3+ SP_Fnum+
CG10376 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint2- Fmph1- NuFluct+(tfr) Rto1-(tfr) Tint4- Tmph1- Tmph2- Tmph3- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10376.
Cell Count:
CG_NumberCategoryR1R2R3
CG10376Primary screen721342168
CG10376Secondary assay110410761228
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10376:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191145-0.1740005322.257354383.978652450.228895688-1.2871412832.8828800387.7701438242.9688734485.8830489374.9281150776.523240541-0.2345770352.6513194991.4216715363.6471030880.9384902366.51928518811.4475329710.375673628.5929318551.5543448658.6366879693.678524377
192291-0.4168921-0.240267692-0.033361808-0.096615925-0.0419418871.1632475212.4397970171.2612743971.25394290.6208886460.836387660.2180000630.9816737691.8960345221.960600979-0.1636654492.3156079882.2446115571.0215849261.312906482-0.813486932-0.583848085-0.647732385
193211.2730247412.6039711823.658347933-0.10659294-0.8733984530.3898389563.082362164-0.2415345770.1158590983.6179605741.1871711541.851765591-0.6337005180.1505546462.1439937373.5048211752.9978903683.4662063445.7023004120.806208007-0.6829331260.0487369421.331331718
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10376Slide16C0.0000.4730.3690.444
CG10376Slide16O0.7410.9121.0991.065
CG10376Slide16P0.0940.8610.8710.629
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10376Slide1F0.6230.9970.9210.990
CG10376Slide1O0.4741.0291.0511.033
CG10376Slide1T0.0030.7450.7480.802
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10376 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein dephosphorylationGO:0006470non-traceable author statement
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine phosphatase activityGO:0004722non-traceable author statement
catalytic activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10376 in FlyBase
FLIGHTClick here to see CG10376 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10376 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10376
Entrez GeneEntrez Gene page for CG10376
UniprotUniprot page for CG10376

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)