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Gene Page - CG Number : CG10377
Gene Summary - CG10377:

CG10377: The gene Heterogeneous nuclear ribonucleoprotein at 27C is referred to in FlyBase by the symbol Dmel\Hrb27C (CG10377, FBgn0004838). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; mRNA 3'-UTR binding; single-stranded DNA binding. There is experimental evidence that it is involved in the biological process: regulation of mRNA splicing, via spliceosome; border follicle cell migration; axon guidance; lateral inhibition; pole plasm oskar mRNA localization; positive regulation of translation; regulation of pole plasm oskar mRNA localization. 34 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; chorion; trichogen cell; egg; mesothoracic tergum; scutellar bristle; posterior supraalar bristle. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages.

Gene summary for CG10377 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10377:CG10377 is perturbed in following parameters in primary screen: Tmph1 Tmph2
CG10377 is not tested in classification assay (fluid).
CG10377 is perturbed in following parameters in classification assay (transferrin): Fint4- Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10377.
Cell Count:
CG_NumberCategoryR1R2R3
CG10377Primary screen212463228
CG10377Secondary assay892775985
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10377:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191147-0.7378132740.027011444-0.635258791-0.586596159-1.71222575-3.503172792-2.712847245-4.490611963-2.1776150460.2794227442.5480677780.173584365-0.735799705-0.0281713841.273890762-1.8716919710.3738869914.564997458-1.516966883-2.820038353-1.068197495-0.7350552240.262257703
192289-0.552518809-0.71357801-0.333045857-0.3626922280.1885074180.3899849050.5392217140.475558162.0091523931.5413531021.7787189150.0520908921.3613012490.9322760371.6767841460.842972834.3160672183.3839119344.127702141.843925749-0.170395965-0.397479665-0.407274956
193194.0619759561.8844529650.981476514-0.305445886-0.2125774150.8456885292.8852659410.1923728320.8882358453.9393009772.6166723513.4414565432.8582412111.58693493.1405288262.7852539963.2204575453.1298370282.8927097751.5280039830.106719427-0.3917525610.077846625
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10377Slide10F0.9391.2360.8220.974
CG10377Slide10O0.5181.0330.9350.907
CG10377Slide10T0.2660.9731.1951.415
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10377 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
negative regulation of oskar mRNA translationGO:0007319traceable author statement
regulation of pole plasm oskar mRNA localization
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
ribonucleoprotein complexGO:0030529non-traceable author statement
ribonucleoprotein complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
mRNA 3'-UTR bindingGO:0003730traceable author statement
mRNA 5'-UTR binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10377 in FlyBase
FLIGHTClick here to see CG10377 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10377 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10377
Entrez GeneEntrez Gene page for CG10377
UniprotUniprot page for CG10377

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)