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Gene Page - CG Number : CG10379
Gene Summary - CG10379:

CG10379: The gene myoblast city is referred to in FlyBase by the symbol Dmel\mbc (CG10379, FBgn0015513). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: myoblast fusion; central nervous system development; dorsal closure; anterior Malpighian tubule development; border follicle cell migration; actin cytoskeleton organization; larval visceral muscle development; activation of Rac GTPase activity; cell competition in a multicellular organism; cytoskeleton organization. 63 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; multicellular structure; organ system subdivision; anatomical structure; non-connected developing system; portion of tissue; embryonic/larval excretory system; hypodermal muscle of larval abdomen; late extended germ band embryo; embryonic/larval hypodermal muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; Dedicator of cytokinesis; Dedicator of cytokinesis A; Dedicator of cytokinesis C-terminal; Dedicator of cytokinesis C2 domain; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10379 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10379:CG10379 is not perturbed in primary screen.
CG10379 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10379.
Cell Count:
CG_NumberCategoryR1R2R3
CG10379Primary screen285425435
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10379:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191148-1.2494955440.168772768-0.184535125-0.389824163-1.483533201-4.025371383-3.466656315-4.50263535-5.117025562-1.633571459-1.222724414-1.097077151-0.427858842-0.8637083780.493964765-1.167433899-2.311067215-1.381942334-2.728005753-4.6672174090.830028517-0.500842682-0.466549171
192288-0.069270155-0.2526911750.00589626-0.0047547050.9472123390.6401185060.4910331510.4795352570.6059326740.216298450.2206417570.706374790.064863212-0.0519097620.7393141841.1614197481.112603466-0.29839452-0.1541215060.7363227070.4330982790.293938256-0.051966285
193180.182202130.665188750.5849962760.1812844741.3094592671.0881803161.2265207931.2209783011.750283410.9456976721.997217468-0.541800221.9129056641.6512216670.3328256631.492117371.6875446611.5374391951.7964696391.866068333-0.723104427-0.4708774110.06932638
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10379 is not tested in classification assay
Integrated Annotations for CG10379 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
myoblast fusionGO:0007520inferred from mutant phenotype
larval visceral muscle development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
ruffleGO:0001726traceable author statement
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with rols
GTP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10379 in FlyBase
FLIGHTClick here to see CG10379 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10379 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10379
Entrez GeneEntrez Gene page for CG10379
UniprotUniprot page for CG10379

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)