Gene Page - CG Number : CG10387

Gene Summary - CG10387:

CG10387: The gene tosca is referred to in FlyBase by the symbol Dmel\tos (CG10387, FBgn0015553). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: exodeoxyribonuclease I activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: DNA repair. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 5'-3' exonuclease, C-terminal domain; DNA repair protein (XPGC)/yeast Rad; Helix-hairpin-helix motif, class 2; XPG N-terminal; XPG conserved site; XPG/RAD2 endonuclease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10387 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10387:

CG10387 is not perturbed in primary screen.
CG10387 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10387.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10387	Primary screen	642	493	318

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10387:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
19	1	153	-0.050078036	0.27709029	-0.529409253	-0.422357712	0.307131774	0.890100145	0.905659827	1.031090131	0.140585209	0.316946589	-0.115604361	-0.347655243	-0.844521487	-0.711438921	-0.265635391	0.544715198	-1.651948466	-0.430566773	-2.833552801	0.985169843	-0.296514053	0.17719262	-0.714869838
19	2	133	-1.115251756	-0.250628108	-0.108463949	-0.461661196	1.182589591	0.032607557	-0.011883973	0.307238326	0.117608932	0.007743862	0.41292406	0.046261345	0.275497967	1.024871044	-0.468049551	1.144227257	-0.005429979	0.164031523	-0.017245982	0.437444679	-0.212257374	-0.039827877	0.354808725
19	3	283	2.085550909	-0.029726119	-0.168301023	-0.584694515	0.42975592	0.603214627	0.935087466	0.7030451	0.980037644	0.510335966	1.59843746	1.894292516	3.331131591	1.417374538	1.28196049	0.237522502	0.986062254	0.533376934	0.791418729	1.016967921	0.351567012	0.693836862	0.505877071

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10387 is not tested in classification assay

Integrated Annotations for CG10387 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
DNA repair	GO:0006281	inferred from electronic annotation with InterPro:IPR006084, InterPro:IPR006085, InterPro:IPR006086

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
-

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
exodeoxyribonuclease I activity	GO:0008852	inferred from sequence or structural similarity with UniProtKB:P53695 nuclease activity

Other annotations

Database	Link
FlyBase	Click here to see CG10387 in FlyBase
FLIGHT	Click here to see CG10387 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10387 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10387
Entrez Gene	Entrez Gene page for CG10387
Uniprot	Uniprot page for CG10387

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)