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Gene Page - CG Number : CG10387
Gene Summary - CG10387:

CG10387: The gene tosca is referred to in FlyBase by the symbol Dmel\tos (CG10387, FBgn0015553). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: exodeoxyribonuclease I activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: DNA repair. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 5'-3' exonuclease, C-terminal domain; DNA repair protein (XPGC)/yeast Rad; Helix-hairpin-helix motif, class 2; XPG N-terminal; XPG conserved site; XPG/RAD2 endonuclease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10387 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10387:CG10387 is not perturbed in primary screen.
CG10387 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10387.
Cell Count:
CG_NumberCategoryR1R2R3
CG10387Primary screen642493318
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10387:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191153-0.0500780360.27709029-0.529409253-0.4223577120.3071317740.8901001450.9056598271.0310901310.1405852090.316946589-0.115604361-0.347655243-0.844521487-0.711438921-0.2656353910.544715198-1.651948466-0.430566773-2.8335528010.985169843-0.2965140530.17719262-0.714869838
192133-1.115251756-0.250628108-0.108463949-0.4616611961.1825895910.032607557-0.0118839730.3072383260.1176089320.0077438620.412924060.0462613450.2754979671.024871044-0.4680495511.144227257-0.0054299790.164031523-0.0172459820.437444679-0.212257374-0.0398278770.354808725
1932832.085550909-0.029726119-0.168301023-0.5846945150.429755920.6032146270.9350874660.70304510.9800376440.5103359661.598437461.8942925163.3311315911.4173745381.281960490.2375225020.9860622540.5333769340.7914187291.0169679210.3515670120.6938368620.505877071
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10387 is not tested in classification assay
Integrated Annotations for CG10387 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
DNA repairGO:0006281inferred from electronic annotation with InterPro:IPR006084, InterPro:IPR006085, InterPro:IPR006086
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
exodeoxyribonuclease I activityGO:0008852inferred from sequence or structural similarity with UniProtKB:P53695
nuclease activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10387 in FlyBase
FLIGHTClick here to see CG10387 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10387 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10387
Entrez GeneEntrez Gene page for CG10387
UniprotUniprot page for CG10387

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)