Gene Page - CG Number : CG10388

Gene Summary - CG10388:

CG10388: The gene Ultrabithorax is referred to in FlyBase by the symbol Dmel\Ubx (CG10388, FBgn0003944). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA binding. There is experimental evidence for 17 unique biological process terms, many of which group under: biological regulation; system development; cell fate commitment; regulation of developmental process; cellular process; appendage development; multicellular organismal development; regulation of RNA metabolic process; mesoderm morphogenesis; renal tubule development; somatic muscle development; post-embryonic organ morphogenesis; specification of organ identity; open tracheal system development; muscle cell differentiation; segment specification; cardiovascular system development. 497 alleles are reported. The phenotypes of these alleles are annotated with 119 unique terms, many of which group under: organ system subdivision; adult segment; organ system; thoracic segment; larval abdominal segment; hypodermal muscle of larval abdomen; non-connected developing system; A1-7 transverse muscle; embryonic thoracic segment; imaginal precursor. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Homeobox protein, antennapedia type, conserved site; Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages.

Gene summary for CG10388 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10388:

CG10388 is not perturbed in primary screen.
CG10388 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10388.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10388	Primary screen	696	705	226

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10388:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
19	1	154	-0.083501503	-0.333317763	1.510378517	-0.508074857	-0.043234914	0.985448371	2.164432313	1.417196148	1.664249923	1.286027453	0.181653093	-0.515146015	0.154409451	0.055445795	-0.260754325	-0.057463291	0.166769071	0.059104151	0.763772297	2.307665076	-0.198836762	4.778683102	4.446154038
19	2	132	0.318645773	0.061482532	0.095308536	-0.351007616	1.048064624	1.026259209	0.799964839	0.844223243	1.402053162	0.467141447	0.594194217	0.176773617	1.449999488	0.216770558	1.174483124	0.64629934	1.525536308	1.241320913	1.057972584	1.426588367	0.087115127	0.875505287	0.421455211
19	3	282	0.504813506	-0.310036577	0.20099911	0.856198502	-0.373589722	-0.164602734	1.418347532	-0.197781831	-0.188890196	1.219709085	0.561637636	-0.573183277	0.45456682	0.355563843	0.271878635	-0.615487324	-0.107347433	-0.038609876	-0.23553864	-0.663862771	1.495003187	-0.778355732	0.404470099

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10388 is not tested in classification assay

Integrated Annotations for CG10388 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
specification of segmental identity, thorax	GO:0007384	inferred from mutant phenotype regulation of transcription, DNA-dependent

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
nucleus	GO:0005634	inferred from direct assay nucleus

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
protein binding	GO:0005515	inferred from physical interaction with DIP1 sequence-specific DNA binding transcription factor activity

Other annotations

Database	Link
FlyBase	Click here to see CG10388 in FlyBase
FLIGHT	Click here to see CG10388 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10388 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10388
Entrez Gene	Entrez Gene page for CG10388
Uniprot	Uniprot page for CG10388

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)