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Gene Page - CG Number : CG10443
Gene Summary - CG10443:

CG10443: The gene Leukocyte-antigen-related-like is referred to in FlyBase by the symbol Dmel\Lar (CG10443, FBgn0000464). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine phosphatase activity; SAM domain binding. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; anatomical structure development; biological regulation; locomotion; growth; taxis; cell projection organization; multicellular organismal reproductive process; protein modification process; macromolecule modification; developmental growth; compound eye photoreceptor development; cell adhesion; regulation of developmental process; regulation of multicellular organismal development; multicellular organism reproduction. 61 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; organ system subdivision; female germline cyst; nervous system; embryonic/larval neuron; germarium; multi-cell-component structure; egg; adult segment; peripheral nervous system. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein-tyrosine phosphatase, active site; Protein-tyrosine phosphatase, receptor/non-receptor type; Protein-tyrosine/Dual-specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period.

Gene summary for CG10443 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10443:CG10443 is perturbed in following parameters in primary screen: Fint3
CG10443 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint2- LP_Fint3- LP_Fint4+ LP_Fmph2- LP_Fnum- NuCellD-(fld) NuFluct-(fld) NuSize-(fld) Okt+(fld) Rto1+ Rto2+ Rto3+ SP_Fclc- SP_Fint4+ SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10443 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10443.
Cell Count:
CG_NumberCategoryR1R2R3
CG10443Primary screen59171165
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10443:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191186-0.4548399840.7055630535.014249389-0.2760471540.6597405264.0939633567.6199693053.0966304443.2464186320.4943190570.959488858-0.7475198840.0978999640.269347865-0.183026691-0.529186562.1565017223.4037527511.6392125716.293901857-0.21257136310.917037645.974722046
1921002.9523416350.5750595630.490133729-1.416723502-1.2343441311.095380447-1.3336870350.169378448-3.157065886-0.054043542-2.008772293-0.4820798060.7023644911.179286777-0.576935566-1.3353424510.201079283-1.596309373-1.927487001-2.1154481181.5819924531.0076628591.20112812
1932505.646324445.9686331616.4725596680.162930619-1.255577284-0.2319840341.68603498-0.930875488-1.406093313-3.154754129-0.8985756690.809486854-1.838046405-2.233129316-0.406749777-2.422793806-4.058036229-1.437768329-4.947130373-1.591075819-0.488812421-0.668362446-0.273719341
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10443Slide4C0.0020.8000.7890.704
CG10443Slide4O0.0331.3481.5161.256
CG10443Slide4P0.3010.9640.9780.845
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10443 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein dephosphorylationGO:0006470inferred from direct assay
axon guidance
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity
integral to membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein tyrosine phosphatase activityGO:0004725inferred from direct assay
transmembrane receptor protein tyrosine phosphatase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10443 in FlyBase
FLIGHTClick here to see CG10443 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10443 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10443
Entrez GeneEntrez Gene page for CG10443
UniprotUniprot page for CG10443

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)