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Gene Page - CG Number : CG10449
Gene Summary - CG10449:

CG10449: The gene Catecholamines up is referred to in FlyBase by the symbol Dmel\Catsup (CG10449, FBgn0002022). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: enzyme regulator activity. There is experimental evidence that it is involved in the biological process: regulation of catecholamine metabolic process; ovarian nurse cell to oocyte transport; border follicle cell migration; regulation of epithelial cell migration, open tracheal system. 65 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; acellular anatomical structure; organ system subdivision; adult segment; sense organ; adult; tracheal system; embryonic/larval hemocoel; adult cuticle; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc/iron permease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages.

Gene summary for CG10449 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10449:CG10449 is perturbed in following parameters in primary screen: Fmph2
CG10449 is perturbed in following parameters in classification assay (fluid): NuCirc-(fld) NuSize+(fld)
CG10449 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10449.
Cell Count:
CG10449Primary screen1056388263
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10449:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10449 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
ovarian nurse cell to oocyte transportGO:0007300inferred from mutant phenotype
regulation of catecholamine metabolic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to plasma membraneGO:0005887non-traceable author statement
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
enzyme regulator activityGO:0030234inferred from mutant phenotype
metal ion transmembrane transporter activity
Other annotations
FlyBaseClick here to see CG10449 in FlyBase
FLIGHTClick here to see CG10449 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10449 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10449
Entrez GeneEntrez Gene page for CG10449
UniprotUniprot page for CG10449

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)