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Gene Page - CG Number : CG1046
Gene Summary - CG1046:

CG1046: The gene zerknullt is referred to in FlyBase by the symbol Dmel\zen (CG1046, FBgn0004053). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; compound eye development; negative regulation of gene expression. 30 alleles are reported. The phenotypes of these alleles are annotated with: embryonic optic lobe primordium; embryonic head; cuticle; extended germ band embryo; optic lobe; presumptive embryonic/larval central nervous system; denticle belt. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG1046 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1046:CG1046 is perturbed in following parameters in primary screen: Fint3 Fmph2
CG1046 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) NuCirc-(fld) NuFluct+(fld) Rto2+ Rto3+ SP_Fint1+ SP_Fint2+
CG1046 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1046.
Cell Count:
CG_NumberCategoryR1R2R3
CG1046Primary screen24786206
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1046:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1046Slide8C0.5210.8520.9121.072
CG1046Slide8O0.2540.9260.9051.012
CG1046Slide8P0.4670.9611.0371.177
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1046 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dorsal/ventral pattern formation, imaginal discGO:0007450non-traceable author statement
dorsal/ventral axis specification
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with UniProtKB:Q08624
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA bindingGO:0043565inferred from direct assay
sequence-specific DNA binding transcription factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1046 in FlyBase
FLIGHTClick here to see CG1046 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1046 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1046
Entrez GeneEntrez Gene page for CG1046
UniprotUniprot page for CG1046

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)