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Gene Page - CG Number : CG10466
Gene Summary - CG10466:

CG10466: This gene is referred to in FlyBase by the symbol Dmel\CG10466 (FBgn0032822). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. It is reported to be involved in the biological process: mRNA splicing, via spliceosome. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages.

Gene summary for CG10466 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10466:CG10466 is not perturbed in primary screen.
CG10466 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint1- LP_Fint2- LP_Fint3- LP_Fint3- LP_Fint4+ LP_Fint4+ LP_Fmph1- LP_Fmph2- LP_Fmph3- LP_Fmph3- LP_Fnum- NuSize-(fld) Okt+(fld) Rto1+ Rto2+ Rto2+ Rto3+ SP_Fclc- SP_Fint3- SP_Fint4+ SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10466 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10466.
Cell Count:
CG_NumberCategoryR1R2R3
CG10466Primary screen483960285
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10466:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1911992.5999889574.526894194.7989858991.975132071-0.543096440.1864161992.6525898190.2565382040.928796458-0.608270489-1.2861583962.1231789351.0844709670.0891998720.247814097-0.5833889282.6527865231.4749222254.3233297752.444000164-0.2897110934.2795451652.308344147
1921173.68896377413.5487118716.9655275811.3365150614.1735403440.9175673227.378486943.5443449418.162272083.1507145221.493194774.0456695750.868951920.06151044820.141569220.867368926.0908276820.1455029463.11692301114.202572478.133173053-2.102983518-2.086670661
193267-0.491361457-0.2031925272.226822779-0.4990468651.4117293212.6174513794.3417949221.3936718630.720963701-0.167801729-0.0966157311.2747825570.5002641710.0585758731.359959936-0.3131480210.716025183-0.2308078240.5745810860.704384404-0.0664208690.226886449-0.108749959
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10466Slide14C0.0010.5140.5020.597
CG10466Slide14O0.2311.4241.3760.953
CG10466Slide14P0.4860.9990.9820.808
CG10466Slide4C0.0710.7370.7880.622
CG10466Slide4O0.0661.3911.1751.517
CG10466Slide4P0.0870.8730.7470.607
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10466 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
nuclear mRNA splicing, via spliceosomeGO:0000398inferred by curator from GO:0071011|GO:0071013
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
precatalytic spliceosomeGO:0071011inferred from direct assay
catalytic step 2 spliceosome
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
mRNA bindingGO:0003729inferred from sequence or structural similarity
nucleic acid binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10466 in FlyBase
FLIGHTClick here to see CG10466 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10466 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10466
Entrez GeneEntrez Gene page for CG10466
UniprotUniprot page for CG10466

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)