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Gene Page - CG Number : CG10477
Gene Summary - CG10477:

CG10477: This gene is referred to in FlyBase by the symbol Dmel\CG10477 (FBgn0035661). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S1/S6, chymotrypsin/Hap; Peptidase S1/S6, chymotrypsin/Hap, active site; Peptidase S1A, chymotrypsin-type; Peptidase cysteine/serine, trypsin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG10477 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10477:CG10477 is perturbed in following parameters in primary screen: Fmph2 Tint2 Tint4 Tmph2
CG10477 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc- LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- NuCirc-(fld) NuFluct+(fld) NuSize+(fld) SP_Fint1+ SP_Fint2+ SP_Fint3+ SP_Fmph2-
CG10477 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) NuSize-(tfr) Tmph1-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10477.
Cell Count:
CG_NumberCategoryR1R2R3
CG10477Primary screen550572259
CG10477Secondary assay12561265954
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10477:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191207-0.7481292650.4289226641.6121614650.02210447-1.2252113931.337904283.5294486280.7914337842.234611322.2907593394.572077173-0.1826970431.0671420860.3253320371.27276531-0.0219258161.9175661626.5590617771.990698053.192523798-0.5943918023.7890024671.325180686
192109-0.137746994-0.1394672390.186201097-0.2998717140.7243989021.6937233943.2374386351.3481422642.2904573811.3459403221.758746403-0.3892777941.7284219410.8242186170.1809121880.5672661462.4996084292.8078145232.7275783442.426152246-0.5067256620.132468019-0.372877762
1932593.3868141671.3971771182.9978786550.7508137941.0311390621.9662966145.0867273411.1527751171.7486545933.5700708043.0452899450.1987796921.2162518691.4419095552.7982750275.3390075774.0743991994.9210678186.625352272.84082107-0.687201020.5494308451.716651272
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10477Slide19C0.0131.3231.5331.310
CG10477Slide19O0.4551.0360.9521.498
CG10477Slide19P0.0421.0971.2921.226
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10477Slide1F0.1031.1521.1031.134
CG10477Slide1O0.3171.0841.2820.994
CG10477Slide1T0.1340.8650.9580.828
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10477 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508non-traceable author statement
proteolysis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175non-traceable author statement
serine-type endopeptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10477 in FlyBase
FLIGHTClick here to see CG10477 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10477 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10477
Entrez GeneEntrez Gene page for CG10477
UniprotUniprot page for CG10477

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)