Gene Page - CG Number : CG10488

Gene Summary - CG10488:

CG10488: The gene eyegone is referred to in FlyBase by the symbol Dmel\eyg (CG10488, FBgn0000625). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: notum development; eye development; antennal development; eye-antennal disc development; compound eye development; negative regulation of transcription from RNA polymerase II promoter; compound eye morphogenesis. 56 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; adult segment; organ system; imaginal precursor; adult; thoracic segment; external compound sense organ; multicellular structure; eo support cell; salivary gland imaginal ring. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like; Paired domain; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages, during early pupal stages.

Gene summary for CG10488 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10488:

CG10488 is not perturbed in primary screen.
CG10488 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10488.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10488	Primary screen	573	24	226

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10488:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
19	1	216	-0.643143123	0.103324178	-1.034343241	-0.404189188	-0.114232469	0.989354527	0.440793291	0.866376333	0.640642615	0.106557189	-0.493701108	-0.809846373	-0.729183571	-0.780392262	-0.066862566	-0.65225198	-2.262300301	-0.817993447	-1.596114153	0.344461475	0.856057553	-0.382894725	-0.384035411
19	2	70	0.635815658	-0.684009399	1.358173638	-0.949639323	-2.446119745	-0.920267883	-1.19412037	-1.037294731	-3.676692356	-1.58951035	-2.761607136	-0.825180813	-1.547253731	-0.446965982	-0.729151553	-1.271945636	-1.499482679	-2.240680134	-2.632469597	-2.084526023	-0.569125347	-1.546520625	0.070907076
19	3	220	6.387603652	3.74292562	4.122918222	1.009938551	2.72654713	2.686386913	7.153519793	2.12620754	0.642044451	-0.617966894	0.536989647	-0.577552845	-0.618563786	-0.467729375	1.679057603	0.416923133	-0.514472827	-0.301803225	-0.638175299	2.057253044	1.166441616	-0.587107906	0.559326483

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10488 is not tested in classification assay

Integrated Annotations for CG10488 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
eye development	GO:0001654	inferred from mutant phenotype compound eye morphogenesis

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
transcription factor complex	GO:0005667	inferred from sequence or structural similarity with MGD:Pax3; MGI:MGI:97487 nucleus

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
sequence-specific DNA binding transcription factor activity	GO:0003700	inferred from sequence or structural similarity with MGD:Pax3; MGI:MGI:97487 sequence-specific DNA binding transcription factor activity

Other annotations

Database	Link
FlyBase	Click here to see CG10488 in FlyBase
FLIGHT	Click here to see CG10488 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10488 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10488
Entrez Gene	Entrez Gene page for CG10488
Uniprot	Uniprot page for CG10488

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)