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Gene Page - CG Number : CG10489
Gene Summary - CG10489:

CG10489: The gene Pole2 is referred to in FlyBase by the symbol Dmel\Pole2 (CG10489, FBgn0035644). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA polymerase alpha/epsilon, subunit B; DNA polymerase epsilon subunit B, N-terminal; DNA polymerase epsilon, subunit B. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.

Gene summary for CG10489 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10489:CG10489 is not perturbed in primary screen.
CG10489 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10489.
Cell Count:
CG_NumberCategoryR1R2R3
CG10489Primary screen720459201
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10489:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191217-0.140467736-0.8881424140.5790512740.4310378050.1335593381.0634323291.1450255061.5486290581.865638497-0.6575781280.264746919-0.7921175910.050880878-0.058682421.4478557860.4068300160.869025417-0.2992852450.6063240092.0880358370.416920422.0075255451.099703005
19269-0.321344922-0.289926077-0.0573440320.2198647120.9893363711.0729055771.009084920.8153526681.201309069-0.2625491670.398905321-0.1296215670.588720221-0.565341062-0.327796470.4484969270.5087310220.0899504610.0050730051.4129068631.479885812-0.1676774730.365062925
1932193.449235879-1.078024802-0.8430996261.271870978-0.865832094-0.694613673-0.856998978-0.706016572-1.556035962-0.846764311-0.3257691730.831587118-0.998951494-0.7524828230.148722327-0.921378826-1.071284922-1.305528685-1.073124616-2.0862867610.161458357-0.3744120840.228031221
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10489 is not tested in classification assay
Integrated Annotations for CG10489 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
DNA-dependent DNA replicationGO:0006261non-traceable author statement
response to DNA damage stimulus
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
epsilon DNA polymerase complexGO:0008622non-traceable author statement
epsilon DNA polymerase complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA-directed DNA polymerase activityGO:0003887inferred from sequence or structural similarity with UniProtKB:P56282
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10489 in FlyBase
FLIGHTClick here to see CG10489 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10489 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10489
Entrez GeneEntrez Gene page for CG10489
UniprotUniprot page for CG10489

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)