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Gene Page - CG Number : CG1049
Gene Summary - CG1049:

CG1049: The gene CTP:phosphocholine cytidylyltransferase 1 is referred to in FlyBase by the symbol Dmel\Cct1 (CG1049, FBgn0041342). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: choline-phosphate cytidylyltransferase activity. There is experimental evidence that it is involved in the biological process: eye development; endocytosis; determination of adult lifespan; oogenesis; imaginal disc-derived wing morphogenesis; establishment of ommatidial planar polarity. 40 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; multicellular structure; cytoplasmic part; external compound sense organ; ovariole; anatomical structure; organ system subdivision; cell part; portion of tissue; peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Cytidyltransferase-like domain; Cytidylyltransferase; Rossmann-like alpha/beta/alpha sandwich fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, in stages of adults of both sexes.

Gene summary for CG1049 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1049:CG1049 is perturbed in following parameters in primary screen: Tint4 Tmph1
CG1049 is not tested in classification assay (fluid).
CG1049 is perturbed in following parameters in classification assay (transferrin): Fint1- Fint2- Fint4- Okt+(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint4- Tmph1- Tmph2- Tmph3-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1049.
Cell Count:
CG_NumberCategoryR1R2R3
CG1049Primary screen524620336
CG1049Secondary assay88810471005
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1049:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1049Slide1F0.0540.9240.8530.910
CG1049Slide1O0.0001.2621.2241.233
CG1049Slide1T0.1120.6960.9500.697
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1049 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
endocytosisGO:0006897inferred from mutant phenotype
establishment of ommatidial planar polarity
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
choline-phosphate cytidylyltransferase activityGO:0004105inferred from sequence or structural similarity
choline-phosphate cytidylyltransferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1049 in FlyBase
FLIGHTClick here to see CG1049 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1049 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1049
Entrez GeneEntrez Gene page for CG1049
UniprotUniprot page for CG1049

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)