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Gene Page - CG Number : CG10504
Gene Summary - CG10504:

CG10504: The gene Integrin linked kinase is referred to in FlyBase by the symbol Dmel\Ilk (CG10504, FBgn0028427). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: apposition of dorsal and ventral imaginal disc-derived wing surfaces; integrin-mediated signaling pathway; cell-matrix adhesion; muscle attachment. 31 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Integrin-linked protein kinase; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during late pupal stages.

Gene summary for CG10504 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10504:CG10504 is not perturbed in primary screen.
CG10504 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint2+ LP_Fint3+ NuCirc+(fld) NuSize-(fld) Okt+(fld) SP_Fint1+ SP_Fint2+ SP_Fint3+
CG10504 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fmph1- Fmph3- Fnum- NuFluct+(tfr) Rto2+(tfr) Tint1+ Tint2+ Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10504.
Cell Count:
CG10504Primary screen194990512
CG10504Secondary assay110914431497
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10504:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10504 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
integrin-mediated signaling pathwayGO:0007229inferred from mutant phenotype AND inferred from sequence or structural similarity
cytoskeletal anchoring at plasma membrane
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
focal adhesionGO:0005925inferred from sequence or structural similarity
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine kinase activityGO:0004674inferred from sequence or structural similarity
protein kinase activity
Other annotations
FlyBaseClick here to see CG10504 in FlyBase
FLIGHTClick here to see CG10504 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10504 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10504
Entrez GeneEntrez Gene page for CG10504
UniprotUniprot page for CG10504

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)