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Gene Page - CG Number : CG10521
Gene Summary - CG10521:

CG10521: The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: motor neuron axon guidance; synaptic target recognition; salivary gland boundary specification; axon guidance; glial cell migration; regulation of photoreceptor cell axon guidance; dendrite guidance. 32 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system subdivision; organ system; peripheral nervous system; adult segment; multicellular structure; cell part; adult; external compound sense organ; embryonic foregut; non-connected developing system; larval abdominal segment; axon. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: EGF-like, laminin; Laminin, N-terminal; Netrin domain; Netrin module, non-TIMP type; Tissue inhibitor of metalloproteinases-like, OB-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period.

Gene summary for CG10521 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10521:CG10521 is perturbed in following parameters in primary screen: Fint2
CG10521 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) CellSize-(fld) LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4+ LP_Fmph1+ LP_Fmph2+ LP_Fmph3+ LP_Fnum+ NuCellD+(fld) NuCirc-(fld) NuFluct+(fld) SP_Fint1+ SP_Fint2+ SP_Fint3+ SP_Fmph1+
CG10521 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10521.
Cell Count:
CG_NumberCategoryR1R2R3
CG10521Primary screen46066472
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10521:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1912310.7779005874.4997431091.1513078840.901229943-1.1059898640.2248392662.1297080320.4668532830.2852770590.167996473-0.4793100191.1671359890.922468715-0.349493634-0.060722786-0.683302752-0.743119615-1.298703021-0.3543249220.667976711-0.4119253290.281818068-0.597615832
192851.0055312066.5995031948.8017937233.2156584553.7473995340.466576267-1.285844981-0.5338146115.6387312630.331989167-1.4730303051.260600475-2.143830676-0.4159226820.4948976647.37520737118.468109937.07865192317.217533253.3761568180.36042306-1.482881274-0.904501227
1932350.230136585-0.154861149-0.081369139-0.2279313351.181545581.4675735022.1106287631.5407714811.766066721.0046184832.097960825-0.7742291451.5584691061.3135489121.3516259690.9860202091.106603720.8382840871.320022831.832852816-0.6017064140.0910590460.007814158
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10521Slide17C0.2541.3041.1890.988
CG10521Slide17O0.7601.0390.9331.089
CG10521Slide17P0.7511.3590.9650.864
CG10521Slide8C0.0491.0831.1371.189
CG10521Slide8O0.1031.0401.2641.237
CG10521Slide8P0.0221.1661.3841.340
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10521 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
axon guidanceGO:0007411inferred from sequence or structural similarity
motor axon guidance
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
extracellular regionGO:0005576inferred from sequence or structural similarity with WB:unc-6; WP:CE04538
proteinaceous extracellular matrix
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
-
Other annotations
DatabaseLink
FlyBaseClick here to see CG10521 in FlyBase
FLIGHTClick here to see CG10521 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10521 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10521
Entrez GeneEntrez Gene page for CG10521
UniprotUniprot page for CG10521

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)