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Gene Page - CG Number : CG10523
Gene Summary - CG10523:

CG10523: The gene parkin is referred to in FlyBase by the symbol Dmel\park (CG10523, FBgn0041100). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity. There is experimental evidence for 11 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; organelle organization; cellular process; macromolecule modification; multicellular organism reproduction; gamete generation; protein modification by small protein conjugation; primary metabolic process; response to stress; protein ubiquitination; cellular component organization. 39 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system; multicellular structure; cytoplasmic part; elongation stage spermatid; organelle; adult; organ system subdivision; anatomical structure; adult segment; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Parkin; Ubiquitin; Ubiquitin subgroup; Ubiquitin supergroup; Zinc finger, C6HC-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed in adult male stages.

Gene summary for CG10523 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10523:CG10523 is not perturbed in primary screen.
CG10523 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10523.
Cell Count:
CG_NumberCategoryR1R2R3
CG10523Primary screen347349339
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10523:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191233-0.3630532653.7229709259.6773619811.1816369520.4636184746.61918474210.791439525.6056567922.4617037982.7811227193.078628514-0.3679410920.308494450.363836274-0.150052931-0.1969406746.6852615636.1754348143.5374325356.275281206-0.9066392449.3555176767.231563866
192830.241841316-0.180438786-0.436174399-0.476164335-0.12973701-0.646246547-0.226277144-1.059018637-0.2689244910.4395504040.4932767170.4198937971.7594310081.544569030.981063130.3589335450.3845889950.065601977-0.072704275-0.086079965-0.498234029-0.328758562-0.065261738
1932330.0781607350.8179489430.0321653640.0305935420.53651580.7993175481.5472740380.8833574941.0459533630.3048447220.557651720.6961783980.7439181140.715349154-0.3911093170.027653180.6644197780.4133655060.4466656310.856342501-0.4772700780.145847411-0.085170127
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10523 is not tested in classification assay
Integrated Annotations for CG10523 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mitochondrion organizationGO:0007005inferred from mutant phenotype
response to oxidative stress
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737inferred from direct assay
mitochondrion
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ubiquitin-protein ligase activityGO:0004842inferred from direct assay
ubiquitin conjugating enzyme binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10523 in FlyBase
FLIGHTClick here to see CG10523 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10523 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10523
Entrez GeneEntrez Gene page for CG10523
UniprotUniprot page for CG10523

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)