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Gene Page - CG Number : CG10537
Gene Summary - CG10537:

CG10537: The gene Resistant to dieldrin is referred to in FlyBase by the symbol Dmel\Rdl (CG10537, FBgn0004244). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: GABA-A receptor activity. There is experimental evidence that it is involved in the biological process: response to mechanical stimulus; negative regulation of synaptic transmission; regulation of olfactory learning; regulation of circadian sleep/wake cycle; sleep. 35 alleles are reported. The phenotypes of these alleles are annotated with: aCC neuron; RP2 neuron; U neuron; metathoracic intersegmental nerve; prothoracic intersegmental nerve; intersegmental nerve; mesothoracic intersegmental nerve; VUM neuron; abdominal intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Gamma-aminobutyric acid A receptor; Gamma-aminobutyric-acid A receptor, beta subunit; Neurotransmitter-gated ion-channel; Neurotransmitter-gated ion-channel ligand-binding; Neurotransmitter-gated ion-channel transmembrane domain; Neurotransmitter-gated ion-channel, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages.

Gene summary for CG10537 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10537:CG10537 is perturbed in following parameters in primary screen: Fmph2
CG10537 is not perturbed in classification assay (fluid).
CG10537 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10537.
Cell Count:
CG_NumberCategoryR1R2R3
CG10537Primary screen742514254
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10537:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191239-0.3667138780.9757881592.841634765-0.8869610510.1811129242.9906382925.5746342733.0499719123.5551315550.7859806722.7048573880.3456109860.5928057311.0238158960.6693666680.4664167531.6769666212.9640087721.7775119244.9846008980.3671194189.1021736634.578534922
192770.628961881-0.24142538-0.148397272-0.3383654420.4648441020.585707720.5745023570.4245107440.636479044-0.1540227760.211898516-0.2287982571.1569520070.477339837-0.1442253451.2425081390.3602399490.728323212-0.0050656480.9026176891.4286760880.159124743-0.202676929
1932270.2012600830.485874360.6542300893.8884937950.2116859631.2363671943.3106024130.1517925770.310468607-0.2680160770.776278977-0.4021461380.2419763370.2060051170.294441389-0.0222945210.2726494870.097923593-0.1070169740.854803120.821002896-0.511445074-0.444267091
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10537Slide26C0.2890.2260.9930.787
CG10537Slide26O0.8690.2862.6120.530
CG10537Slide26P0.1350.0860.7490.665
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10537 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
response to cyclodieneGO:0046682non-traceable author statement
negative regulation of synaptic transmission
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity
integral to membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
GABA-A receptor activityGO:0004890non-traceable author statement
GABA-A receptor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10537 in FlyBase
FLIGHTClick here to see CG10537 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10537 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10537
Entrez GeneEntrez Gene page for CG10537
UniprotUniprot page for CG10537

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)