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Gene Page - CG Number : CG10539
Gene Summary - CG10539:

CG10539: The gene RPS6-p70-protein kinase is referred to in FlyBase by the symbol Dmel\S6k (CG10539, FBgn0015806). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ribosomal protein S6 kinase activity. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; response to stress; growth; neuron differentiation; cellular process; positive regulation of cellular metabolic process; neuron projection development; response to DNA damage stimulus; larval feeding behavior; determination of adult lifespan; multicellular organism reproduction. 28 alleles are reported. The phenotypes of these alleles are annotated with: adult; eye; salivary gland; wing disc; trichogen cell; oocyte; wing blade; wing; ommatidium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Ribosomal protein S6 kinase; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages.

Gene summary for CG10539 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10539:CG10539 is not perturbed in primary screen.
CG10539 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10539.
Cell Count:
CG_NumberCategoryR1R2R3
CG10539Primary screen525422156
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10539:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191242-0.628305587-0.332610489-0.5084210080.6188072370.0445468080.5252451630.0479141440.7453151240.5969506090.86850615-1.2178269761.521629159-0.2501498280.4891503810.728083283-0.18866399-0.661976819-0.400053236-0.1659004140.623697865-0.4746097351.2990704351.278904853
19244-0.672905640.7765431841.322861814-0.3313366720.1189401180.0787977740.543096893-0.083113176-0.129070886-0.423555575-0.4267733962.060837354-0.821104289-0.814296084-0.7674285850.2671006521.795314525-0.5704293550.3666527680.295372905-0.567303541-0.4948975380.57585611
193194-0.780240833-0.8527580510.5554715210.815424082-1.793691165-2.337782936-2.982114857-2.281974798-2.552364043-2.54741016-1.8525249251.314467601-2.410030653-0.7464317990.480750598-2.119659738-2.579802995-2.336859206-3.556013376-3.0483004972.0721987770.6411911331.290490665
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10539 is not tested in classification assay
Integrated Annotations for CG10539 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
positive regulation of cell sizeGO:0045793inferred from mutant phenotype
positive regulation of multicellular organism growth
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
ribosomeGO:0005840inferred from sequence or structural similarity
presynaptic active zone
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ribosomal protein S6 kinase activityGO:0004711inferred from direct assay AND inferred from sequence or structural similarity
protein serine/threonine kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10539 in FlyBase
FLIGHTClick here to see CG10539 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10539 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10539
Entrez GeneEntrez Gene page for CG10539
UniprotUniprot page for CG10539

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)