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Gene Page - CG Number : CG10545
Gene Summary - CG10545:

CG10545: The gene G protein β-subunit 13F is referred to in FlyBase by the symbol Dmel\Gβ13F (CG10545, FBgn0001105). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. There is experimental evidence that it is involved in the biological process: asymmetric neuroblast division; actin filament organization. 18 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; embryonic neuroblast; mesothoracic tergum. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: G-protein beta WD-40 repeat; G-protein, beta subunit; Guanine nucleotide-binding protein, beta subunit; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages.

Gene summary for CG10545 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10545:CG10545 is perturbed in following parameters in primary screen: Fint3
CG10545 is perturbed in following parameters in classification assay (fluid): LP_Fint2+ LP_Fmph2- LP_Fnum- NuCellD+(fld) NuSize-(fld) Rto1- Rto2- SP_Fint1-
CG10545 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10545.
Cell Count:
CG10545Primary screen37727740
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10545:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10545 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
actin filament organizationGO:0007015inferred from mutant phenotype
G-protein coupled receptor signaling pathway
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
heterotrimeric G-protein complexGO:0005834inferred from sequence or structural similarity with UniProtKB:O45040
heterotrimeric G-protein complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
GTPase activityGO:0003924inferred from sequence or structural similarity with UniProtKB:O45040
GTPase activity
Other annotations
FlyBaseClick here to see CG10545 in FlyBase
FLIGHTClick here to see CG10545 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10545 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10545
Entrez GeneEntrez Gene page for CG10545
UniprotUniprot page for CG10545

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)