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Gene Page - CG Number : CG1057
Gene Summary - CG1057:

CG1057: The gene Mediator complex subunit 31 is referred to in FlyBase by the symbol Dmel\MED31 (CG1057, FBgn0037262). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription coactivator activity. There is experimental evidence that it is involved in the biological process: transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; anterior/posterior axis specification, embryo. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Mediator complex, subunit Med31. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG1057 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1057:CG1057 is perturbed in following parameters in primary screen: Fmph2 Okt Tint1 Tint2 Tint3 Tmph1 Tmph2 Tmph3
CG1057 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint1+ LP_Fint3- NuCellD+(fld) NuCirc-(fld) NuFluct+(fld) SP_Fclc- SP_Fint3- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG1057 is perturbed in following parameters in classification assay (transferrin): CellSize+(tfr) Fint1- NuCirc-(tfr) NuFluct+(tfr) NuSize+(tfr) Okt+(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1057.
Cell Count:
CG_NumberCategoryR1R2R3
CG1057Primary screen18316485
CG1057Secondary assay1079528481
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1057:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1057Slide10C0.0570.6490.8920.776
CG1057Slide10O0.8161.3310.9260.861
CG1057Slide10P0.0790.5380.7370.879
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1057Slide1F0.0810.9460.7440.778
CG1057Slide1O0.0401.6531.2941.424
CG1057Slide1T0.6011.1880.7600.799
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1057 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
transcription initiation from RNA polymerase II promoterGO:0006367inferred from sequence or structural similarity
transcription initiation from RNA polymerase II promoter
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
mediator complexGO:0016592inferred from sequence or structural similarity
mediator complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
transcription coactivator activityGO:0003713contributes_to inferred from direct assay
RNA polymerase II transcription cofactor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1057 in FlyBase
FLIGHTClick here to see CG1057 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1057 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1057
Entrez GeneEntrez Gene page for CG1057
UniprotUniprot page for CG1057

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)