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Gene Page - CG Number : CG10572
Gene Summary - CG10572:

CG10572: The gene Cyclin-dependent kinase 8 is referred to in FlyBase by the symbol Dmel\Cdk8 (CG10572, FBgn0015618). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein kinase activity; RNA polymerase II transcription cofactor activity. There is experimental evidence that it is involved in the biological process: chaeta development; axon guidance; sex comb development; imaginal disc-derived leg segmentation; protein phosphorylation; mitotic cell cycle G2/M transition DNA damage checkpoint; cell cycle. 9 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10572 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10572:CG10572 is not perturbed in primary screen.
CG10572 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10572.
Cell Count:
CG_NumberCategoryR1R2R3
CG10572Primary screen572335257
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10572:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191259-0.2321257721.422060042-0.4679763510.683369633-1.108632091-2.141855828-0.354307672-2.649095347-0.127684354-0.330542530.785686134-0.824300662-0.193543399-0.4351175310.5508419570.3750724921.0399165391.0823307460.774317234-0.5282315541.1100918242.3758922560.611135576
19257-0.1440819371.7737505910.668190529-0.5301287630.105670762.0216097091.8081582651.9780810260.9884791880.7667030080.9456628061.14893790.8804190580.987228525-0.4103978230.0705209493.2860943241.6887021080.6709711781.0162339430.148739207-0.511674292-0.495852027
1932075.0051709723.1689223392.0928321413.335568053-0.1742073130.2016330634.6363396350.184748354-0.031382944-1.779817956-1.3930293722.9070485243.686724581.942500955-0.678762379-0.060084925-2.901990149-1.246949787-3.417180852-0.2920368660.274210372-0.111283373-0.14024073
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10572 is not tested in classification assay
Integrated Annotations for CG10572 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
transcription initiation from RNA polymerase II promoterGO:0006367inferred from sequence or structural similarity
protein phosphorylation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
mediator complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine kinase activityGO:0004674non-traceable author statement
cyclin-dependent protein kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10572 in FlyBase
FLIGHTClick here to see CG10572 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10572 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10572
Entrez GeneEntrez Gene page for CG10572
UniprotUniprot page for CG10572

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)