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Gene Page - CG Number : CG10574
Gene Summary - CG10574:

CG10574: The gene Inhibitor-2 is referred to in FlyBase by the symbol Dmel\I-2 (CG10574, FBgn0028429). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein phosphatase inhibitor activity; protein phosphatase 1 binding. There is experimental evidence that it is involved in the biological process: negative regulation of protein dephosphorylation. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein phosphatase inhibitor 2 (IPP-2). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG10574 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10574:CG10574 is not perturbed in primary screen.
CG10574 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc- LP_Fint2- LP_Fint3- LP_Fmph1+ LP_Fmph2+ LP_Fmph3+ Rto1- Rto2- Rto3- SP_Fint1- SP_Fint2- SP_Fint3- SP_Fint4- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10574 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10574.
Cell Count:
CG10574Primary screen388440376
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10574:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10574 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
negative regulation of protein dephosphorylationGO:0035308inferred from direct assay
negative regulation of protein dephosphorylation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein phosphatase inhibitor activityGO:0004864inferred from direct assay
protein phosphatase inhibitor activity
Other annotations
FlyBaseClick here to see CG10574 in FlyBase
FLIGHTClick here to see CG10574 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10574 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10574
Entrez GeneEntrez Gene page for CG10574
UniprotUniprot page for CG10574

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)