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Gene Page - CG Number : CG10575
Gene Summary - CG10575:

CG10575: The gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase is referred to in FlyBase by the symbol Dmel\Ppat-Dpck (CG10575, FBgn0035632). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pantetheine-phosphate adenylyltransferase activity; dephospho-CoA kinase activity. There is experimental evidence that it is involved in the biological process: triglyceride homeostasis; cytoplasmic transport, nurse cell to oocyte; imaginal disc-derived wing morphogenesis; ovarian follicle cell migration. 5 alleles are reported. The phenotypes of these alleles are annotated with: follicle cell; wing; embryonic/larval brain; egg chamber. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytidyltransferase-like domain; Cytidylyltransferase; Dephospho-CoA kinase; Rossmann-like alpha/beta/alpha sandwich fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes.

Gene summary for CG10575 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10575:CG10575 is perturbed in following parameters in primary screen: Fmph1 Fmph2 Fmph3
CG10575 is perturbed in following parameters in classification assay (fluid): LP_Fclc- Rto2+ SP_Fint1+ SP_Fint2+ SP_Fint3+ SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10575 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10575.
Cell Count:
CG_NumberCategoryR1R2R3
CG10575Primary screen403549398
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10575:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1912633.14335014614.6902401511.945341792.9760735311.6013712187.88195767512.3198974110.034269946.2688212193.9126849723.5038951994.3496300232.9840793761.37897541-0.007115534-0.4351882544.7499497929.6647794346.3877198459.233392083-0.5318095692.0931085460.934448409
192530.000337276-0.14131488-0.347629145-0.6021488740.3391008513.3030036393.5334666023.165007862.044987750.701875110.88754801-0.3601023951.050587340.867742685-0.6806158970.3300204711.0545673141.4342946470.9357492812.177493283-0.2339607170.137055747-0.510496192
1932030.161281096-0.2471151560.4618982950.0419814051.0447547941.896951484.1956586231.3551874441.6829303620.5610361120.9266003020.8649146751.6313015220.7711032871.0863998460.5327404821.2446764610.9466880281.189926671.9451867360.822779713-0.33845129-0.50589656
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10575Slide4C0.1891.1521.1671.342
CG10575Slide4O0.1571.4841.5371.017
CG10575Slide4P0.0471.1671.2611.419
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10575 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
coenzyme A biosynthetic processGO:0015937inferred from sequence alignment with MGD:Coasy; MGI:MGI:1918993
triglyceride homeostasis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
dephospho-CoA kinase activityGO:0004140inferred from sequence alignment with MGD:Coasy; MGI:MGI:1918993
pantetheine-phosphate adenylyltransferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10575 in FlyBase
FLIGHTClick here to see CG10575 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10575 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10575
Entrez GeneEntrez Gene page for CG10575
UniprotUniprot page for CG10575

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)